Evidence map›Paper›PMID 30413561›Full record

ArticleDevelopment (Cambridge, England)2018

Novel initiator caspase reporters uncover previously unknown features of caspase-activating cells.

Luis Alberto Baena-Lopez, Lewis Arthurton, Marcus Bischoff, Jean-Paul Vincent, Cyrille Alexandre, Reuben McGregor

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. An atlas of caspase cleavage events in differentiating muscle cells.Protein science : a publication of the Protein Society · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Orchestration of Force Generation and Nuclear Collapse in Apoptotic Cells.International journal of molecular sciences · 2021
    Review
  18. The Duality of Caspases in Cancer, as Told through the Fly.International journal of molecular sciences · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Luis Alberto Baena-LopezSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxfordshire, OX1 3RE, UK alberto.baenalopez@path.ox.ac.uk.ORCID 0000-0002-8663-3794
Lewis ArthurtonSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxfordshire, OX1 3RE, UK.
Marcus BischoffBiomolecular Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, Scotland, KY16 9ST, UK.
Jean-Paul VincentThe Francis Crick Institute, Midland Road, London, NW1 1AT, UK.ORCID 0000-0003-2305-5744
Cyrille AlexandreThe Francis Crick Institute, Midland Road, London, NW1 1AT, UK.
Reuben McGregorFaculty of Medical and Health Sciences, Molecular Medicine & Pathology, The University of Auckland, M&HS Building 502, 85 Park Road, Grafton, Auckland 1023, New Zealand.
The Francis Crick Institute · GBUniversity of Oxford · GBUniversity of Auckland · NZUniversity of St Andrews · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M021084/1Cancer Research UK 17516Cancer Research UK C49979/A17516Medical Research Council U117584268
6 · The paper itself

Abstract

The caspase-mediated regulation of many cellular processes, including apoptosis, justifies the substantial interest in understanding all of the biological features of these enzymes. To complement functional assays, it is crucial to identify caspase-activating cells in live tissues. Our work describes novel initiator caspase reporters that, for the first time, provide direct information concerning the initial steps of the caspase activation cascade in

Indexed as

Genes, ReporterAnimalsApoptosisCaspasesCell MovementCell NucleusCell SurvivalCell TrackingDigestive SystemDrosophila melanogasterDrosophila ProteinsEnzyme ActivationFemaleTime FactorsTime-Lapse ImagingWings, AnimalCaspasesdrICE protein, DrosophilaDrosophila ProteinsApical caspase reporterApoptotic nuclear migrationHistorical caspase reporterInterkinetic nuclear migrationNon-apoptotic caspase functions

Identifiers

PMID30413561
PMCPMC6288387
OpenAlexW2899601976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.