ArticleDevelopment (Cambridge, England)2018
Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.
Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The anti-neural role of BMP signaling is a consequence of its ancestral function in dorsoventral patterning.PLoS biology · 2026Article
- Early nervous system development in the chaetognathFrontiers in cell and developmental biology · 2026Article
- Single-nucleus profiling highlights the all-brain echinoderm nervous system.Science advances · 2025Article
- Transcription of microRNAs is regulated by developmental signaling pathways and transcription factors.Frontiers in cell and developmental biology · 2024Article
- NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis.Nature communications · 2023Article
- The brain regulatory program predates central nervous system evolution.Scientific reports · 2023Article
- Early expression onset of tissue-specific effector genes during the specification process in sea urchin embryos.EvoDevo · 2023Article
- Thyroid hormone membrane receptor binding and transcriptional regulation in the sea urchinFrontiers in endocrinology · 2023Article
- microRNA-124 regulates Notch and NeuroD1 to mediate transition states of neuronal development.Developmental neurobiology · 2023Article
- An ancestral Wnt-Brachyury feedback loop in axial patterning and recruitment of mesoderm-determining target genes.Nature ecology & evolution · 2022Article
- Homologous gene regulatory networks control development of apical organs and brains in Bilateria.Science advances · 2022Article
- Evolutionary Changes in the Chromatin Landscape Contribute to Reorganization of a Developmental Gene Network During Rapid Life History Evolution in Sea Urchins.Molecular biology and evolution · 2022Article
- Partial exogastrulation due to apical-basal polarity of F-actin distribution disruption in sea urchin embryo by omeprazole.Genes to cells : devoted to molecular & cellular mechanisms · 2022Article
- Development of a larval nervous system in the sea urchin.Current topics in developmental biology · 2022Review
- FISH for All: A Fast and Efficient FluorescentFrontiers in physiology · 2022Article
- Single-cell RNA sequencing of theeLife · 2021Article
- Developmental origin of peripheral ciliary band neurons in the sea urchin embryo.Developmental biology · 2020Article
- Spatial and temporal patterns of gene expression during neurogenesis in the sea urchinEvoDevo · 2019Article
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3 authors.
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Abstract
Many marine larvae begin feeding within a day of fertilization, thus requiring rapid development of a nervous system to coordinate feeding activities. Here, we examine the patterning and specification of early neurogenesis in sea urchin embryos. Lineage analysis indicates that neurons arise locally in three regions of the embryo. Perturbation analyses showed that when patterning is disrupted, neurogenesis in the three regions is differentially affected, indicating distinct patterning requirements for each neural domain. Six transcription factors that function during proneural specification were identified and studied in detail. Perturbations of these proneural transcription factors showed that specification occurs differently in each neural domain prior to the Delta-Notch restriction signal. Though gene regulatory network state changes beyond the proneural restriction are largely unresolved, the data here show that the three neural regions already differ from each other significantly early in specification. Future studies that define the larval nervous system in the sea urchin must therefore separately characterize the three populations of neurons that enable the larva to feed, to navigate, and to move food particles through the gut.
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