Evidence map›Paper›PMID 30413362›Full record

ArticleImmunity2018

Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.

Mounia S Braza, Mandy M T van Leent, Marnix Lameijer, Brenda L Sanchez-Gaytan, Rob J W Arts, Carlos Pérez-Medina, Patricia Conde, Mercedes R Garcia, Maria Gonzalez-Perez, Manisha Brahmachary and 23 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 1 synthesis or guideline pooled it, 242 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Review
  4. Innate Immune Memory Responses in Organ Transplantation.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  5. Review
  6. Review
  7. Inhibition of CD154:CD11b interactions using a novel nanotherapeutic improves allograft survival.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  8. Suppression of cardiac allograft vasculopathy by a macrophage efferocytosis receptor.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  9. Erythropoietin prolongs graft survival in mice by counteracting trained immunity.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
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95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors at 13 institutions in 5 countries.

Mounia S BrazaTranslational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mandy M T van LeentTranslational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marnix LameijerDepartment of Medical Biochemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.
Brenda L Sanchez-GaytanTranslational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rob J W ArtsDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Carlos Pérez-MedinaTranslational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Patricia CondeTransplant Immunology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
Mercedes R GarciaTransplant Immunology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
Maria Gonzalez-PerezTransplant Immunology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
Manisha BrahmacharyDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Francois FayTranslational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ewelina KluzaDepartment of Medical Biochemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.
Susanne KossatzDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Regine J DressSingapore Immunology Network (SIgN), A STAR, Singapore, Singapore.
Fadi SalemDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alexander RialdiDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Thomas ReinerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Radiology, Weill Cornell Medical College, New York, NY, USA.
Peter BorosDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gustav J StrijkersTranslational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, the Netherlands.
Claudia C CalcagnoTranslational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Florent GinhouxSingapore Immunology Network (SIgN), A STAR, Singapore, Singapore.
Ivan MarazziDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Esther LutgensDepartment of Medical Biochemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands; Institute for Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany.
Gerry A F NicolaesDepartment of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands.
Christian WeberDepartment of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands.
Filip K SwirskiCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Matthias NahrendorfCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Edward A FisherDepartment of Medicine (Cardiology), New York University School of Medicine, New York, NY, USA.
Raphaël DuivenvoordenTranslational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Nephrology, Academic Medical Center, Amsterdam, the Netherlands; Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.
Zahi A FayadTranslational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
Willem J M MulderTranslational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medical Biochemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands. Electronic address: willem.mulder@mssm.edu.
Jordi OchandoDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Transplant Immunology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: jordi.ochando@mssm.edu.
Imaging Center · USIcahn School of Medicine at Mount Sinai · USInstituto de Salud Carlos III · ESAmsterdam UMC Location University of Amsterdam · NLHarvard University · USMaastricht University · NLMemorial Sloan Kettering Cancer Center · USSingapore Immunology Network · SGUniversity of Amsterdam · NLLudwig-Maximilians-Universität München · DENew York University · USRadboud University Nijmegen · NLUniversity of Bonn · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Translational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Filip K Swirski · 2017 to 2026
$24.3M
Theranostic HDL nanoparticles for inflammatory macrophages in atherosclerosisR01EB009638 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2009 to 2016
$4.6M
TRAF6 Nanoimmunotherapy to resolve plaque inflammationR01HL144072 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2018 to 2021
$3.3M
PET/MRI to study nanotherapy in atherosclerosisR01HL125703 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MULDER, WILLEM · 2015 to 2018
$2.4M
Anti-inflammatory nanoparticle formulations to treat atherosclerosisR01HL118440 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MULDER, WILLEM, NAHRENDORF, MATTHIAS · 2014 to 2017
$2.3M
Myeloid Specific Targeted Nanoimunotherapy for Organ Transplant AcceptanceR01AI139623 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI OCHANDO, JORDI · 2018 to 2022
$2.3M
Bioorthogonal Strategies for Targeted PET Imaging Probe DevelopmentK25EB016673 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI REINER, THOMAS · 2013 to 2015
$525k
NCI NIH HHS P30 CA008748NHLBI NIH HHS HHSN268201000045CNHLBI NIH HHS P01 HL131478NHLBI NIH HHS R01 HL118440NHLBI NIH HHS R01 HL125703NHLBI NIH HHS R01 HL144072NIAID NIH HHS R01 AI139623NIBIB NIH HHS K25 EB016673NIBIB NIH HHS R01 EB009638
6 · The paper itself

Abstract

Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transplantation. Using an experimental transplantation mouse model, we demonstrate that local macrophage activation through dectin-1 and toll-like receptor 4 (TLR4) drives trained immunity-associated cytokine production during allograft rejection. We conducted nanoimmunotherapeutic studies and found that a short-term mTOR-specific high-density lipoprotein (HDL) nanobiologic treatment (mTORi-HDL) averted macrophage aerobic glycolysis and the epigenetic modifications underlying inflammatory cytokine production. The resulting regulatory macrophages prevented alloreactive CD8

Indexed as

Immunosuppression TherapyOrgan TransplantationAllograftsAnimalsBiomarkersGraft SurvivalHMGB1 ProteinImmune ToleranceImmunity, InnateImmunologic MemoryInflammationMacrophagesMiceMyeloid CellsTOR Serine-Threonine KinasesVimentinBiomarkersHMGB1 ProteinTOR Serine-Threonine KinasesVimentinCD40immunotherapyinnate immune memorymTORnanoimmunotherapyTRAF6trained immunitytransplantation

Identifiers

PMID30413362
PMCPMC6251711
OpenAlexW2899726004

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.