Evidence map›Paper›PMID 30413312›Full record

Trial reportThe Journal of pediatrics2019

Different Growth Patterns Persist at 24 Months of Age in Formula-Fed Infants Randomized to Consume a Meat- or Dairy-Based Complementary Diet from 5 to 12 Months of Age.

Minghua Tang, Vivianne Andersen, Audrey E Hendricks, Nancy F Krebs

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02142647 (Effects of Dietary Protein From Meat vs. Dairy on Infant Growth, Body Composition and Gut Health), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02142647 nacompletednot on this map

Effects of Dietary Protein From Meat vs. Dairy on Infant Growth, Body Composition and Gut Health

TypeinterventionalSponsorUniversity of Colorado, DenverRan2014 to 2018Enrolled75ConditionsInfant Growth, Infant Body Fat, Infant Gut MicrobiomeArmsa high-protein complementary diet with meat, a high-protein complementary diet with dairy
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Minghua TangSection of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO. Electronic address: Minghua.Tang@ucdenver.edu.
Vivianne AndersenUniversity of Colorado School of Medicine, Aurora, CO.
Audrey E HendricksDepartment of Mathematical and Statistical Science, University of Colorado Denver, Aurora, CO.
Nancy F KrebsSection of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Protein Quality Early in Life: Mechanisms of Growth and Later Obesity DevelopmentK01DK111665 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI TANG, MINGHUA · 2016 to 2019
$537k
NCATS NIH HHS UL1 TR001082NIDDK NIH HHS K01 DK111665
6 · The paper itself

Abstract

objectiveTo test the long-term effect on growth status at 24 months of age in formula-fed infants who were randomized to consume a meat- or dairy-based complementary diet from 5 to 12 months of age. STUDY

designObservational assessments, including anthropometric, dietary, and blood biomarkers, were conducted at 24 months of age, 1 year after the intervention ended.

resultsThe retention rate at 24 months of age was 84% for the meat group and 81% for the dairy group. Mean (±SD) protein intakes at 24 months of age were 4.1 ± 1.2 and 4.0 ± 1.1 g/kmeat (n = 27) and dairy (n = 26) groups, respectively, and comparable with the estimates of US population intake. At 24 months of age, weight-for-age z score did not differ significantly between groups and was similar to that at 12 months. Length-for-age z score remained significantly higher in the meat group compared with the dairy group, and the average length was 1.9 cm greater in the meat group. Weight-for-length z score also did not differ significantly between groups. Insulin-like growth factor 1 significantly increased from 12 to 24 months of age in both groups, but insulin-like growth factor-binding protein 3 and blood urea nitrogen did not change significantly from 12 to 24 months of age and were comparable between groups.

conclusionsThe protein source-induced distinctive growth patterns observed during infancy persisted at 24 months of age, suggesting a potential long-term impact of early protein quality on growth trajectories in formula-fed infants.

trial registrationClinicalTrials.gov: NCT02142647.

Indexed as

Dairy ProductsDietInfant FormulaInfant Nutritional Physiological PhenomenaMeatAnimalsAnthropometryBiomarkersBirth WeightBody WeightChild, PreschoolDietary ProteinsEnergy IntakeFemaleHumansInfantBiomarkersDietary Proteinsfollow-upgrowthinfantprotein source

Identifiers

PMID30413312
PMCPMC6389371

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.