Evidence map›Paper›PMID 30413185›Full record

ArticleBMC neuroscience2018

Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats.

Armando Valenzuela Peraza, David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Hugo Juárez Olguín, Miroslava Lindoro Silva, Belén Juárez Tapia, Gerardo Barragán Mejía

Open access · goldAbstract read
In one paragraph

Article in BMC neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Armando Valenzuela PerazaLaboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), Mexico City, Mexico.
David Calderón GuzmánLaboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), Mexico City, Mexico.
Norma Osnaya BrizuelaLaboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), Mexico City, Mexico.
Maribel Ortiz HerreraLaboratorio de Bacteriología Experimental, INP, Mexico City, Mexico.
Hugo Juárez OlguínLaboratorio de Farmacología, Instituto Nacional de Pediatría (INP), y Facultad de Medicina, Universidad Nacional Autónoma de México, Av Imán #1, 3er piso, Col Cuicuilco, CP 04530, Mexico City, Mexico. juarezol@yahoo.com.ORCID 0000-0002-1405-1728
Miroslava Lindoro SilvaLaboratorio de Farmacología, Instituto Nacional de Pediatría (INP), y Facultad de Medicina, Universidad Nacional Autónoma de México, Av Imán #1, 3er piso, Col Cuicuilco, CP 04530, Mexico City, Mexico.
Belén Juárez TapiaLaboratorio de Farmacología, Instituto Nacional de Pediatría (INP), y Facultad de Medicina, Universidad Nacional Autónoma de México, Av Imán #1, 3er piso, Col Cuicuilco, CP 04530, Mexico City, Mexico.
Gerardo Barragán MejíaLaboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), Mexico City, Mexico.
Instituto Nacional de Pediatria · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeurological disorders suggest that the excitotoxicity involves a drastic increase in intracellular Ca

methodsMale Fisher rats were grouped (n = 6) and treated as follows: group 1, control (NaCl 0.9%); group 2, 3-NPA (20 mg/kg); group 3, B MAIN

findingsLevels of dopamine increased in cortex, striatum and cerebellum/medulla oblongata of animals that received 3-NPA alone. The lipid peroxidation increased in cortex, striatum, and cerebellum/medulla oblongata, of animals treated with B

conclusionThe results confirm the capacity of 3-NPA to generate oxidative stress. Besides, the study suggests that B

Indexed as

AnimalsAntioxidantsBrainDopamineFree RadicalsHuntington DiseaseMaleNeuroprotective AgentsNitro CompoundsOxidative StressPropionatesPyridoxineRats, Inbred F344Rats, WistarRiboflavin3-nitropropionic acidAntioxidantsDopamineFree RadicalsNeuroprotective AgentsNitro CompoundsPropionatesPyridoxineRiboflavinBrainHuntington animal modelOxidative stressPyridoxineRiboflavin

Identifiers

PMID30413185
PMCPMC6230234
OpenAlexW2899898316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.