ArticleBMC pharmacology & toxicology2018
Fractal properties and morphological investigation of Nano hydrochlorothiazide is used to treat hypertension.
Article in BMC pharmacology & toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Role of Organic and Inorganic Nanoparticles in the Drug Delivery System for Hypertension Treatment: A Systematic Review.Current cardiology reviews · 2022Pooled it
- Review
- The Fractal Viewpoint of Tumors and Nanoparticles.Current medicinal chemistry · 2023Review
- BrainFD: Measuring the Intracranial Brain Volume With Fractal Dimension.Frontiers in aging neuroscience · 2021Article
- Fractal properties and morphological investigation of Nano hydrochlorothiazide is used to treat hypertension.BMC pharmacology & toxicology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHigh blood pressure (hypertension) is a relatively common condition that increases blood pressure in the arteries abnormally, causing problems such as heart disease and stroke. Blood pressure is a force that is felt through the walls of the blood vessels and has a direct relationship to the power of pumping the heart and vascular resistance to the blood flow. One of the lowing of blood pressure medications is hydrochlorothiazide (Hctz) which is used to treat high blood pressure and swelling from heart failure, liver damage, and other minor actions. PROCEDURES: This study explains the effectiveness of Hctz with the help of "fractal dimension". To perfect investigate the fractal dimension, we used the Hctz drug nanoparticle form then using MATLAB software, homogeneity levels or heterogeneity of Nano Hctz using SEM images were computed.
resultsWe calculated histogram plot with SEM image by MATLAB software which that its standard deviation was eclose to zero and it can explain that the scattering of data is low and their amount is in one suffering. Fractal dimensions obtained from Matlab and SPSS software for normal distribution, correlation, standard deviation, mean, cumulative frequency and variance analysis were analyzed.
conclusionsIn this research, the association between Hctz treatment effects with the point of view of the fractal dimension of the drug was demonstrated to prove the properties of the drug in the body. in the near future, drug fractal studies can improve the development of new drugs and treatments with minimal cost than clinical approaches by linking chemistry, mathematical sciences and pharmaceutical sciences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.