Evidence map›Paper›PMID 30413070›Full record

ArticleInternational journal of molecular sciences2018

Toxicity Evaluation and Biomarker Selection with Validated Reference Gene in Embryonic Zebrafish Exposed to Mitoxantrone.

Lili Liu, Hua Zhu, Yanchun Yan, Peng Lv, Wei Wu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Aqueous Extract ofAntioxidants (Basel, Switzerland) · 2022
    Article
  5. Article
  6. Frontiers in pharmacology · 2022
    Article
  7. Article
  8. Roots and stems ofPharmaceutical biology · 2020
    Article
  9. Toxicity Reduction ofMolecules (Basel, Switzerland) · 2019
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lili LiuBeijing Key Laboratory of Fishery Biotechnology, Beijing Fisheries Research Institute, Beijing 100068, China. lilyinmay@163.com.ORCID 0000-0001-8608-6471
Hua ZhuBeijing Key Laboratory of Fishery Biotechnology, Beijing Fisheries Research Institute, Beijing 100068, China. zhuhua@bjfishery.com.
Yanchun YanGraduate School, Chinese Academy of Agricultural Sciences, Beijing 100081, China. yanyanchun@caas.cn.
Peng LvGraduate School, Chinese Academy of Agricultural Sciences, Beijing 100081, China. lvchosen1@163.com.
Wei WuGraduate School, Chinese Academy of Agricultural Sciences, Beijing 100081, China. wuwei02@caas.cn.

Funding

Beijing Municipal Science and Technology Project Z161100004516003Beijing Postdoctoral Research Foundation 2018ZZ058National Natural Science Foundation of China 31170119
6 · The paper itself

Abstract

Notwithstanding the widespread use and promising clinical value of chemotherapy, the pharmacokinetics, toxicology, and mechanism of mitoxantrone remains unclear. To promote the clinical value in the treatment of human diseases and the exploration of potential subtle effects of mitoxantrone, zebrafish embryos were employed to evaluate toxicity with validated reference genes based on independent stability evaluation programs. The most stable and recommended reference gene was

Indexed as

AnimalsBiomarkersEmbryo, NonmammalianGene Expression Regulation, DevelopmentalLarvaMitoxantroneNervous SystemNeurotoxicity SyndromesToxicity TestsZebrafishZebrafish ProteinsBiomarkersMitoxantroneZebrafish Proteinsbiomarker selectionmitoxantronereference genesstability evaluationtoxicity evaluationzebrafish embryos

Identifiers

PMID30413070
PMCPMC6274943

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.