Evidence map›Paper›PMID 30413047›Full record

ReviewPharmaceutics2018

Targeting Groups Employed in Selective Dendrons and Dendrimers.

Rodrigo Vieira Gonzaga, Soraya da Silva Santos, Joao Vitor da Silva, Diego Campos Prieto, Debora Feliciano Savino, Jeanine Giarolla, Elizabeth Igne Ferreira

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rodrigo Vieira GonzagaFaculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil. gonzaga.rodrigo.v@gmail.com.
Soraya da Silva SantosFaculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil. soraya.ssantos@yahoo.com.br.
Joao Vitor da SilvaFaculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil. vitorjvs@live.com.
Diego Campos PrietoFaculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil. diego.campos.prieto@gmail.com.
Debora Feliciano SavinoFaculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil. deborasavino@gmail.com.
Jeanine GiarollaFaculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil. jeanineg@usp.br.
Elizabeth Igne FerreiraFaculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil. elizabeth.igne@gmail.com.

Funding

CNPq 422928/2016-0, 309989/2015-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/19438-1
6 · The paper itself

Abstract

The design of compounds with directed action to a defined organ or tissue is a very promising approach, since it can decrease considerably the toxicity of the drug/bioactive compound. For this reason, this kind of strategy has been greatly important in the scientific community. Dendrimers, on the other hand, comprise extremely organized macromolecules with many peripheral functionalities, stepwise controlled synthesis, and defined size. These nanocomposites present several biological applications, demonstrating their efficiency to act in the pharmaceutical field. Considering that, the main purpose of this review was describing the potential of dendrons and dendrimers as drug targeting, applying different targeting groups. This application has been demonstrated through interesting examples from the literature considering the last ten years of publications.

Indexed as

biomedical applicationdendrimersdendronstargeting groups

Identifiers

PMID30413047
PMCPMC6320891

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.