Evidence map›Paper›PMID 30413044›Full record

ArticleViruses2018

Effects of

Helen R Freyberger, Yunxiu He, Amanda L Roth, Mikeljon P Nikolich, Andrey A Filippov

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. AFrontiers in microbiology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Immunomodulatory Effects ofBiomedicines · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Considerations for the Use of Phage Therapy in Clinical Practice.Antimicrobial agents and chemotherapy · 2022
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Helen R FreybergerDepartment of Bacteriophage Therapeutics, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. helen.r.freyberger.ctr@mail.mil.
Yunxiu HeDepartment of Bacteriophage Therapeutics, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. yunxiu.he.ctr@mail.mil.
Amanda L RothDepartment of Bacteriophage Therapeutics, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. amanda.j.roth.mil@mail.mil.
Mikeljon P NikolichDepartment of Bacteriophage Therapeutics, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. mikeljon.p.nikolich.civ@mail.mil.
Andrey A FilippovDepartment of Bacteriophage Therapeutics, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. andrey.a.filippov.ctr@mail.mil.
Walter Reed Army Institute of Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A potential concern with bacteriophage (phage) therapeutics is a host-versus-phage response in which the immune system may neutralize or destroy phage particles and thus impair therapeutic efficacy, or a strong inflammatory response to repeated phage exposure might endanger the patient. Current literature is discrepant with regard to the nature and magnitude of innate and adaptive immune response to phages. The purpose of this work was to study the potential effects of

Indexed as

Gene ExpressionCytokinesDendritic CellsHost SpecificityHumansMonocytesPhage TherapyStaphylococcal InfectionsStaphylococcus aureusStaphylococcus PhagesVirus ReplicationCytokinesbacteriophage Kcytokines and activation markershuman dendritic cellsStaphylococcus aureus

Identifiers

PMID30413044
PMCPMC6266804
OpenAlexW2899856057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.