Evidence map›Paper›PMID 30413031›Full record

ArticleMarine drugs2018

6-Bromoindole Derivatives from the Icelandic Marine Sponge

Xiaxia Di, Caroline Rouger, Ingibjorg Hardardottir, Jona Freysdottir, Tadeusz F Molinski, Deniz Tasdemir, Sesselja Omarsdottir

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  4. Therapeutic, and pharmacological prospects of nutmeg seed: A comprehensive review for novel drug potential insights.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023
    Review
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  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Xiaxia DiFaculty of Pharmaceutical Sciences, University of Iceland, Hagi, Hofsvallagata 53, IS-107 Reykjavik, Iceland. xid1@hi.is.ORCID 0000-0002-5557-5798
Caroline RougerGEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Marine Natural Products Chemistry Research Unit, GEOMAR Helmholtz Centre for Ocean Research Kiel, Am Kiel-Kanal 44, 24106 Kiel, Germany. caroline.rouger@u-bordeaux.fr.ORCID 0000-0002-6442-6567
Ingibjorg HardardottirDepartment of Immunology and Centre for Rheumatology Research Landspitali-The National University Hospital of Iceland, Hringbraut, IS-101 Reykjavik, Iceland. ih@hi.is.ORCID 0000-0003-0178-7047
Jona FreysdottirDepartment of Immunology and Centre for Rheumatology Research Landspitali-The National University Hospital of Iceland, Hringbraut, IS-101 Reykjavik, Iceland. jonaf@landspitali.is.ORCID 0000-0001-9461-182X
Tadeusz F MolinskiDepartment of Chemistry and Biochemistry and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA. tmolinski@ucsd.edu.
Deniz TasdemirGEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Marine Natural Products Chemistry Research Unit, GEOMAR Helmholtz Centre for Ocean Research Kiel, Am Kiel-Kanal 44, 24106 Kiel, Germany. dtasdemir@geomar.de.
Sesselja OmarsdottirFaculty of Pharmaceutical Sciences, University of Iceland, Hagi, Hofsvallagata 53, IS-107 Reykjavik, Iceland. sesselo@hi.is.
University of Iceland · ISChristian-Albrechts-Universität zu Kiel · DEGEOMAR Helmholtz Centre for Ocean Research Kiel · DEUniversity of California San Diego · US

Funding

An Integrated Methodology for Nanomole-Scale Structure Elucidation of Natural ProductsR21AT009783 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOLINSKI, TADEUSZ F · 2018 to 2019
$426k
AVS R&D Fund of Ministry of Fisheries and Agriculture in Iceland R 14 029-14Landspitali University Hospital Research Fund NAMemory Fund of Helga Jonsdottir and Sigurlidi Kristjansson NANational Institutes of Health R21 AT009783-01NCCIH NIH HHS R21 AT009783University of Iceland Research Fund (Doctoral Grant and Project Grant) NA
6 · The paper itself

Abstract

An UPLC-qTOF-MS-based dereplication study led to the targeted isolation of seven bromoindole alkaloids from the sub-Arctic sponge

Indexed as

Aquatic OrganismsGeodiaAlkaloidsAnimalsAnti-Inflammatory AgentsCD4-Positive T-LymphocytesCell DifferentiationCells, CulturedCoculture TechniquesDendritic CellsHumansIcelandIndolesInhibitory Concentration 50Interleukin-10Interleukin-12 Subunit p406-bromoindoleAlkaloidsAnti-Inflammatory AgentsbarettinIL10 protein, humanIL12B protein, humanIndolesInterleukin-10Interleukin-12 Subunit p40Peptides, Cyclic6-bromoindoleanti-inflammatory activitydendritic cellsGeodia barrettiT cell differentiation

Identifiers

PMID30413031
PMCPMC6266195
OpenAlexW2899982769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.