Evidence map›Paper›PMID 30413022›Full record

ArticleInternational journal of molecular sciences2018

Dexamethasone Inhibits Synergistic Induction of PDE4B Expression by Roflumilast and Bacterium NTHi.

Byung-Cheol Lee, Seiko Susuki-Miyata, Chen Yan, Jian-Dong Li

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Byung-Cheol LeeCenter for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. microlbc@korea.ac.kr.ORCID 0000-0001-5163-3586
Seiko Susuki-MiyataCenter for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. se.miyata@ono.co.jp.
Chen YanAab Cardiovascular Research Institute and Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA. chen_yan@urmc.rochester.edu.ORCID 0000-0002-1397-6358
Jian-Dong LiCenter for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. jdli@gsu.edu.
Georgia State University · USUniversity of Rochester Medical Center · US

Funding

Combinational Regulation of Inflammation in Otitis MediaR01DC005843 · NIDCD · UNIVERSITY OF ROCHESTER · PI LI, JIAN-DONG · 2002 to 2016
$5.4M
Regulation and Function of Phosphodiesterase in the HeartR01HL088400 · NHLBI · UNIVERSITY OF ROCHESTER · PI YAN, CHEN · 2008 to 2018
$3.1M
Development of innovative therapeutics for otitis mediaR01DC015557 · NIDCD · GEORGIA STATE UNIVERSITY · PI KOHANE, DANIEL S, LI, JIAN-DONG · 2018 to 2022
$2.9M
PDE10A Regulation and Function in Cardiovascular DiseaseR01HL134910 · NHLBI · UNIVERSITY OF ROCHESTER · PI BERK, BRADFORD C, YAN, CHEN · 2017 to 2020
$2.1M
Pathogenesis of pneumococcal otitis mediaR01DC013833 · NIDCD · GEORGIA STATE UNIVERSITY · PI LI, JIAN-DONG · 2015 to 2019
$1.6M
NF-kappaB Regulation by Human PirinR01GM107529 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI LI, JIAN-DONG, LIU, AIMIN · 2014 to 2017
$1.0M
NHLBI NIH HHS HL088400NHLBI NIH HHS HL134910NIDCD NIH HHS DC005843NIDCD NIH HHS DC013833NIDCD NIH HHS DC015557NIDCD NIH HHS R01 DC005843NIDCD NIH HHS R01 DC013833NIDCD NIH HHS R01 DC015557NIGMS NIH HHS GM107529NIGMS NIH HHS R01 GM107529
6 · The paper itself

Abstract

Phosphodiesterase 4B (PDE4B) plays an important role in inflammation. Recently we have reported that roflumilast as a PDE4-selective inhibitor, synergizes with nontypeable

Indexed as

AminopyridinesAnimalsBenzamidesCell LineCyclic Nucleotide Phosphodiesterases, Type 4CyclopropanesDexamethasoneDisease Models, AnimalEpithelial CellsGene Expression Regulation, BacterialHaemophilus influenzaeHumansInflammationLungPulmonary Disease, Chronic ObstructiveAminopyridinesBenzamidesCyclic Nucleotide Phosphodiesterases, Type 4CyclopropanesDexamethasonePDE4B protein, humanRoflumilastdexamethasoneglucocorticoid receptornontypeable Haemophilus influenzaePDE4Broflumilast

Identifiers

PMID30413022
PMCPMC6274694
OpenAlexW2900391954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.