Evidence map›Paper›PMID 30412859›Full record

ArticleVirology2019

Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2.

Nigel Bourne, Brianne N Banasik, Clarice L Perry, Aaron L Miller, Mellodee White, Richard B Pyles, Gregg N Milligan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Vaccines to prevent genital herpes.Translational research : the journal of laboratory and clinical medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nigel BourneDepartment of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA; Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA.
Brianne N BanasikDepartment of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA.
Clarice L PerryDepartment of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA.
Aaron L MillerDepartment of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA.
Mellodee WhiteDepartment of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA.
Richard B PylesDepartment of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA; Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA.
Gregg N MilliganDepartment of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA; Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0436, USA. Electronic address: gnmillig@utmb.edu.
The University of Texas Medical Branch at Galveston · US

Funding

Induction, maintenance, and function of genital tract-resident CD8+ T cellsR01AI107784 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MILLIGAN, GREGG N. · 2015 to 2019
$1.7M
Therapeutic immunization to impact HSV-2 latency and associated pathogenesisR21AI105962 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BOURNE, NIGEL · 2013 to 2014
$414k
NIAID NIH HHS R01 AI107784NIAID NIH HHS R21 AI105962
6 · The paper itself

Abstract

Most analyses of genital immunity to herpes simplex virus type 2 (HSV-2) have been performed in females, consequently immune protection of the male genital epithelium is incompletely understood. We developed a model of male genital HSV-2 infection resulting from intrarectal inoculation of guinea pigs. Vesicular lesions developed transiently on the perineum and foreskin concurrent with acute virus shedding. Virus shedding and recurrent genital lesions were also detected after establishment of a latent infection. Analysis of perineum and foreskin RNA detected transcripts for IFNγ, proinflammatory and regulatory cytokines, and for genes involved in migration and regulation of leukocytes. HSV-specific T cells were detected in lymphoid and genital tissues after resolution of the primary infection whereas virus-specific antibody secreting cells were detected only in lymphoid tissue. Taken together, the ability to quantify pathogenesis and local immunity in this guinea pig model represent an important advance towards understanding immunity to HSV-2 in males.

Indexed as

AnimalsAntibodies, ViralCytokinesDisease Models, AnimalForeskinGene ExpressionGenitalia, MaleGuinea PigsHerpes GenitalisHerpesvirus 2, HumanMalePerineumT-LymphocytesVirus SheddingAntibodies, ViralCytokinesForeskinGene expressionHSV-2IFNγMale guinea pigMicroarrayPerineum

Identifiers

PMID30412859
PMCPMC6289718
OpenAlexW2900260857

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.