Evidence map›Paper›PMID 30412729›Full record

ArticleEuropean journal of pharmacology2019

The serotonin 2C receptor agonist WAY-163909 attenuates ketamine-induced hypothermia in mice.

Tyler J Murphy, Kevin S Murnane

Abstract read
In one paragraph

Article in European journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Hyperthermia and Serotonin: The Quest for a "Better Cyproheptadine".International journal of molecular sciences · 2022
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Effect of the 5-HTInternational journal of molecular sciences · 2019
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Tyler J MurphyDepartment of Biology, Oglethorpe University, Atlanta, GA, USA.
Kevin S MurnaneDepartment of Pharmaceutical Sciences, Mercer University College of Pharmacy, Mercer University Health Sciences Center, Atlanta, GA, USA. Electronic address: murnane_ks@mercer.edu.
Mercer University Health Sciences Center · USOglethorpe University · US

Funding

Receptor pharmacology and toxicology of second-generation pyrrolidine "bath salt" cathinonesR21DA040907 · NIDA · NORTHEASTERN UNIVERSITY · PI CANAL, CLINTON E, MURNANE, KEVIN SEAN · 2016 to 2017
$493k
A novel neuropeptide brain delivery system for epilepsyR21NS100512 · NINDS · MERCER UNIVERSITY MACON · PI ESCAYG, ANDREW P, MURNANE, KEVIN SEAN · 2016 to 2017
$440k
NIDA NIH HHS R21 DA040907NINDS NIH HHS R21 NS100512
6 · The paper itself

Abstract

Anesthesia-Induced Hypothermia (AIH) has been reported to be the cause of many postoperative adverse effects, including increased mortality, decreased immune responses, cardiac events, and a greater prevalence of postoperative surgical wound infections. AIH can in some cases be minimized with pre-warming fluids and gases and forced-air heating systems, but such techniques are not always effective and can result in patient burns or other adverse effects. Stimulation of 5-HT

Indexed as

AnimalsAzepinesBody TemperatureHypothermiaIndolesKetamineMaleMiceReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor Agonists1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indoleAzepinesIndolesKetamineReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor Agonists5-HTAnesthesiaHypothermiaKetamineSerotoninWAY-163909

Identifiers

PMID30412729
PMCPMC6296880
OpenAlexW2900424974

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.