Observational studyMetabolism: clinical and experimental2019
Leptin trajectories from birth to mid-childhood and cardio-metabolic health in early adolescence.
Observational study in Metabolism: clinical and experimental, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Sexual dimorphism of leptin and adiposity in children between 0 and 10 years: a systematic review and meta-analysis.Biology of sex differences · 2022Pooled it
- Metabolic health conditions in pregnancy, human milk hormone concentrations, and infant adiposity.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Review
- Review on the Relationship Between TyG Index and CVD Incidence in Patients With T2DM With NAFLD.International journal of endocrinology · 2026Review
- Transition of clinical biomarker status from childhood into adolescence-A prospective study in children from eight European countries.PloS one · 2025Article
- Leptin and adiposity measures from birth to later childhood: Findings from the Hyperglycemia and Adverse Pregnancy Outcomes Follow-Up Study.Pediatric obesity · 2024Article
- Hepatic transcriptome signatures in mice and humans with nonalcoholic fatty liver disease.Animal models and experimental medicine · 2023Article
- Neonatal Leptin Levels Predict the Early Childhood Developmental Assessment Scores of Preterm Infants.Nutrients · 2023Article
- Influence of systolic blood pressure trajectory on in-hospital mortality in patients with sepsis.BMC infectious diseases · 2023Article
- Paternal dietary ratio of n-6: n-3 polyunsaturated fatty acids programs offspring leptin expression and gene imprinting in mice.Frontiers in nutrition · 2022Article
- Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life.European journal of nutrition · 2021Article
- Separating Algorithms From Questions and Causal Inference With Unmeasured Exposures: An Application to Birth Cohort Studies of Early Body Mass Index Rebound.American journal of epidemiology · 2021Article
- Neonatal and Adolescent Adipocytokines as Predictors of Adiposity and Cardiometabolic Risk in Adolescence.Obesity (Silver Spring, Md.) · 2021Article
- Review
- Associations of maternal diet and placenta leptin methylation.Molecular and cellular endocrinology · 2020Article
- Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels.International journal of molecular sciences · 2020Article
- The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD).Journal of diabetes research · 2020Review
- Childhood adiposity trajectories: discerning order amongst the chaos.The American journal of clinical nutrition · 2019Article
- Early-Life Predictors of Systolic Blood Pressure Trajectories From Infancy to Adolescence: Findings From Project Viva.American journal of epidemiology · 2019Article
- Smoking and other determinants of bone turnover.PloS one · 2019Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesLeptin is a hormone produced by adipose tissue that promotes satiety, and some evidence suggests that greater early life leptin exposure prevents excessive adiposity gain in later life. However, few studies have analyzed dynamic changes in leptin throughout childhood in relation to later cardio-metabolic health. Our study aims to identify distinct leptin trajectories in childhood, and to examine their associations with cardio-metabolic outcomes in adolescence.
methodsAmong children in the Project Viva cohort born 1999-2002 in Massachusetts, we used latent class growth models to identify leptin trajectories independent of maternal BMI, child sex, race/ethnicity, size at birth and current age and size among 1360 children with leptin measured at least once at birth, early childhood (mean 3.3 ± SD 0.3 years), or mid-childhood (7.9 ± 0.8 years). At research visits in early adolescence (13.2 ± 0.9 years), we assessed cardio-metabolic outcomes including adiposity measures, fasting biomarkers, and blood pressure among 855 children. We then applied multiple regression models to examine associations of the leptin trajectories with these cardio-metabolic outcomes in early adolescence, adjusting for child age at outcome, maternal age, education, prenatal smoking and glucose, total gestational weight gain and paternal BMI.
resultsThe latent class growth model identified 3 distinct leptin trajectories: "low stable" (n = 1031, 75.8%), "high-decreasing" (n = 219, 16.1%) and "intermediate-increasing" (n = 110, 8.1%). In adjusted models, the intermediate-increasing leptin trajectory was associated with higher early adolescence adiposity measures (e.g. BMI z-score: 0.62 units; 95% confidence interval: 0.28, 0.96 and odds of obesity: 2.84: 1.17, 6.94), but lower systolic blood pressure (-0.46 z-score units; -0.74, -0.18), compared to the low-stable group.
conclusionsOur findings on leptin trajectories in childhood suggest important differences and associations with later metabolic outcomes.
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