ArticleBioanalysis2018
Quantitative profiling of cortisol metabolites in human urine by high-resolution accurate-mass MS.
Article in Bioanalysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02500472 (Investigation of Kava Effects on the Metabolism of the Tobacco-specific Carcinogen 4-), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Kava Effects on the Metabolism of the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Humans
Who cites it
14 citing papers in PubMed.
- How post-translational modifications impact glucocorticoid receptor function in human pathologies.Cell communication and signaling : CCS · 2026Review
- Cortisol Stability at 16 and 30 Years in Urine Specimens Stored at -20°C.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Article
- Urine Metabolomic Patterns to Discriminate the Burnout Levels and Night-Shift-Related Stress in Healthcare Professionals.Metabolites · 2025Article
- LC-HRMS and GC-MS Profiling of Urine Free Cortisol, Cortisone, 6Β-, and 18-Hydroxycortisol for the Evaluation of Glucocorticoid and Mineralocorticoid Disorders.Biomolecules · 2024Article
- The hydrocortisone-responsive urinary metabolome of premature infants.Pediatric research · 2023Article
- Recognition of Nonneoplastic Hypercortisolism in the Evaluation of Patients With Cushing Syndrome.Journal of the Endocrine Society · 2023Article
- Opportunities and Challenges of Kava in Lung Cancer Prevention.International journal of molecular sciences · 2023Review
- Bioassay-Guided Fractionation Leads to the Detection of Cholic Acid Generated by the RareMarine drugs · 2022Article
- Quantification of cortisol and its metabolites in human urine by LC-MSAnalytical and bioanalytical chemistry · 2022Article
- Integrated analysis of the gut microbiome and metabolome in a mouse model of inflammation-induced colorectal tumors.Frontiers in microbiology · 2022Article
- Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes.Frontiers in pharmacology · 2021Article
- Dried urine and salivary profiling for complete assessment of cortisol and cortisol metabolites.Journal of clinical & translational endocrinology · 2020Article
- The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers.Cancer prevention research (Philadelphia, Pa.) · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Aim, materials & methods: Urinary cortisol profile has the potential as a diagnostic biomarker. We therefore developed a stable-isotope dilution ultraperformance chromatography multistage MS-based method to quantify cortisol and 16 metabolites in human urines. Results & conclusion: The LOD for cortisol and its metabolites ranges from 0.02 to 5.81 pg/μl urine. The inter- and intraday variations were 3.7-12.9% and 3.5-15.6%, respectively. Among the metabolites analyzed, significant person-to-person heterogeneity was observed, demonstrating the need for comprehensive metabolite profiling in diagnosis. Nevertheless, the glucuronides of dihydrocortisol, dihydrocortisone, tetrahydrocortisol, allo-tetrahydrocortisol and tetrahydrocortisone are the major ones. The sum of the glucuronidated and free forms constitute >93% of the metabolites analyzed, which is termed as total cortisol equivalent. Total cortisol equivalent may serve as a surrogate of cortisol secretion. Clinical trial registration number: NCT02500472.
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Registered trials
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