ReviewRestorative neurology and neuroscience2018
Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness - a review.
Review in Restorative neurology and neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04037384 (Alternative Home Training Possibilities for Glaucoma Patients), which is not on this map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Alternative Home Training Possibilities for Glaucoma Patients
Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Early visual training and environmental adaptation for infants with visual impairment.Developmental medicine and child neurology · 2021Trial
- Comparison of Quality of Life Questionnaires in Patients with Low VisionTurkish journal of ophthalmology · 2021Trial
- Dual Mechanisms of Impaired Visual Processing in Glaucoma: Insights From Resting-State and Task-Related EEG.Investigative ophthalmology & visual science · 2026Article
- Transcranial Direct Current Stimulation (tDCS) for the Treatment of Hemolacria Comorbid With Psychiatric and Somatic Symptoms: A Case Report.Clinical case reports · 2026Article
- The rAAV2-ND1 gene therapy for Leber hereditary optic neuropathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Review
- Eye yoga for glaucoma: recovery of vascular dysregulation and visual field function-a randomized controlled trial.The EPMA journal · 2025Article
- Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain.Frontiers in cell and developmental biology · 2025Review
- Individualized functional magnetic resonance imaging neuromodulation enhances visuospatial perception: a proof-of-concept study.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Integrative neurovascular coupling and neurotransmitter analyses in anisometropic and visual deprivation amblyopia children.iScience · 2024Article
- Oxidative Model of Retinal Neurodegeneration Induced by Sodium Iodate: Morphofunctional Assessment of the Visual Pathway.Antioxidants (Basel, Switzerland) · 2023Article
- Virtual reality as a means to explore assistive technologies for the visually impaired.PLOS digital health · 2023Article
- Nanocarriers for the Delivery of Neuroprotective Agents in the Treatment of Ocular Neurodegenerative Diseases.Pharmaceutics · 2023Review
- Vascular dysregulation in glaucoma: retinal vasoconstriction and normal neurovascular coupling in altitudinal visual field defects.The EPMA journal · 2023Article
- Male Stressed Mice Having Behavioral Control Exhibit Escalations in Dorsal Dentate Adult-Born Neurons and Spatial Memory.International journal of molecular sciences · 2023Article
- Mental health and visual acuity in patients with age-related macular degeneration.BMC ophthalmology · 2022Article
- Leber Hereditary Optic Neuropathy: Molecular Pathophysiology and Updates on Gene Therapy.Biomedicines · 2022Review
- Age-Related Effects on the Spectrum of Cerebral Visual Impairment in Children With Cerebral Palsy.Frontiers in human neuroscience · 2022Article
- Biodistribution of intravitrealMolecular therapy. Methods & clinical development · 2021Article
- Beneficial effect of mindfulness based stress reduction on optic disc perfusion in primary open angle glaucoma: A randomized controlled trial.Journal of traditional and complementary medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vision loss due to ocular diseases such as glaucoma, optic neuropathy, macular degeneration, or diabetic retinopathy, are generally considered an exclusive affair of the retina and/or optic nerve. However, the brain, through multiple indirect influences, has also a major impact on functional visual impairment. Such indirect influences include intracerebral pressure, eye movements, top-down modulation (attention, cognition), and emotionally triggered stress hormone release affecting blood vessel dysregulation. Therefore, vision loss should be viewed as the result of multiple interactions within a "brain-eye-vascular triad", and several eye diseases may also be considered as brain diseases in disguise. While the brain is part of the problem, it can also be part of the solution. Neuronal networks of the brain can "amplify" residual vision through neuroplasticity changes of local and global functional connectivity by activating, modulating and strengthening residual visual signals. The activation of residual vision can be achieved by different means such as vision restoration training, non-invasive brain stimulation, or blood flow enhancing medications. Modulating brain functional networks and improving vascular regulation may offer new opportunities to recover or restore low vision by increasing visual field size, visual acuity and overall functional vision. Hence, neuroscience offers new insights to better understand vision loss, and modulating brain and vascular function is a promising source for new opportunities to activate residual vision to achieve restoration and recovery to improve quality of live in patients suffering from low vision.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.