Evidence map›Paper›PMID 30412507›Full record

ArticleJournal of neonatal-perinatal medicine2019

Impact of red blood cell transfusions on intestinal barrier function in preterm infants.

O O Ajayi, N L Davis, B Saleem, S Kapoor, A C Okogbule-Wonodi, R M Viscardi, Sripriya Sundararajan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neonatal-perinatal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

O O AjayiDepartment of Pediatrics, University of Maryland School of Medicine, Division of Neonatology Baltimore, MD, USA.
N L DavisDepartment of Pediatrics, University of Maryland School of Medicine, Division of Neonatology Baltimore, MD, USA.
B SaleemDepartment of Pediatrics, University of Maryland School of Medicine, Division of Neonatology Baltimore, MD, USA.
S KapoorDepartment of Pediatrics, University of Maryland School of Medicine, Division of Neonatology Baltimore, MD, USA.
A C Okogbule-WonodiDepartment of Pediatrics, Howard University College of Medicine, Division of Neonatology, Washington, DC, USA.
R M ViscardiDepartment of Pediatrics, University of Maryland School of Medicine, Division of Neonatology Baltimore, MD, USA.
Sripriya SundararajanDepartment of Pediatrics, University of Maryland School of Medicine, Division of Neonatology Baltimore, MD, USA.
University of Maryland, Baltimore · USHoward University · US

Funding

Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonatesR34AT006945 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI FASANO, ALESSIO, VISCARDI, ROSE MARIE · 2011 to 2013
$679k
NCCIH NIH HHS R34 AT006945
6 · The paper itself

Abstract

objectiveTo determine the relationships of red blood cell (RBC) transfusion and enteral feeding to changes in intestinal permeability (IP) measured by the relative intestinal uptake of lactulose (La) and rhamnose (Rh) in preterm infants <33 wk gestation. DESIGN/

methodsInfants 240-326wk gestation received La/Rh solution enterally on study days 1, 8 and 15.Urinary La/Rh ratio was measured by HPLC. Hematocrit preceding transfusion, total RBC transfusion volume, volume/kg, and feeding status during each study interval (birth-d1; d1-d8, and d8-d15) were determined.

resultsOf the seventeen (40.5%) subjects who received≥1 transfusion during the study period, 12 (70.6%) infants were <28 wk gestation and 5 (29.4%) infants were≥28 wk gestation, p < 0.0001. Lower pre-transfusion hematocrit was observed in intervals preceding high IP (La/Rh > 0.05) than in intervals preceding low IP (La/Rh≤0.05) measurements (33 vs 35.8, p = 0.1051). RBC transfusions occurred more frequently in intervals preceding high IP than in intervals preceding low IP (26.8%; vs 8.3%, p = 0.0275) with 5-fold higher total RBC volume and volume/kg in intervals preceding any time point with high IP. RBC transfusion during an interval was associated with a three-fold increased risk of high IP (aOR 2.7; 95% C.I 0.564-12.814; p = 0.2143). Exclusive breast milk exposure and post-menstrual age reduced the risk for high IP following RBC transfusion.

conclusionsBoth RBC transfusion number and volume was associated with subsequent high IP measurements in preterm infants <33 weeks gestation and potentially may contribute to impairment of the preterm intestinal barrier.

Indexed as

Erythrocyte TransfusionEnteral NutritionFemaleGestational AgeHematocritHumansInfant FormulaInfant, NewbornInfant Nutritional Physiological PhenomenaInfant, PrematureIntestinal AbsorptionIntestinal MucosaLactoseMaleMilk, HumanRetrospective StudiesLactoseRhamnoseenteral feedingintestinal permeabilitypremature infantsRed blood cell transfusion

Identifiers

PMID30412507
PMCPMC7891311
OpenAlexW2899548361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.