Evidence map›Paper›PMID 30412486›Full record

SynthesisJournal of Alzheimer's disease : JAD2018

A Systematic Review and Meta-Analysis on the Prevalence of Dementia in Europe: Estimates from the Highest-Quality Studies Adopting the DSM IV Diagnostic Criteria.

Ilaria Bacigalupo, Flavia Mayer, Eleonora Lacorte, Alessandra Di Pucchio, Fabrizio Marzolini, Marco Canevelli, Teresa Di Fiandra, Nicola Vanacore

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06983119 (OPENING OF A MEMORY CLINIC IN THE PROVINCE OF PAVIA), which is not on this map. Cited by 65 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06983119 narecruitingnot on this mapstarted 2024, after this paper: background citation

OPENING OF A MEMORY CLINIC IN THE PROVINCE OF PAVIA: Evaluation of Case-finding Strategies and Care for People With Cognitive Decline and Their Caregivers.

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2024 to 2026Enrolled490ConditionsDementia, Mild Cognitive ImpairmentArmsCase-finding for Neurocognitive Disorders
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Early detection of hearing loss in older adults: the public audiology service in Italy, 2021-2023.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
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  15. Article
  16. Single-cell landscape of sex-specific drivers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  18. Observational
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ilaria BacigalupoNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Flavia MayerNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Eleonora LacorteNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Alessandra Di PucchioNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Fabrizio MarzoliniNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Marco CanevelliDepartment of Human Neuroscience "Sapienza" University of Rome, Rome, Italy.
Teresa Di FiandraGeneral Directorate for Health Prevention, Ministry of Health, Rome, Italy.
Nicola VanacoreNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDementia, including Alzheimer's disease (AD), is one of the most burdensome medical conditions. Usually, the reviews that aim at calculating the prevalence of dementia include estimates from studies without assessing their methodological quality. Alzheimer's Disease International (ADI) proposed a score to assess the methodological quality of population-based studies aimed at estimating the prevalence of dementia. During the last three years, the European Commission has funded three projects (Eurodem, EuroCoDe, and ALCOVE) in order to estimate the prevalence of dementia in Europe.

objectiveThe aim of this study was to perform a systematic review and meta-analysis of data on the prevalence of dementia in Europe derived from studies that included only subjects with a diagnosis of dementia according to the DSM IV criteria, and that had a high quality score according to ADI criteria.

methodsWe considered the studies selected by the two projects EuroCoDe (1993-2007) and Alcove (2008-2011), and we performed a new bibliographic search. For the systematic review, we only selected the subset of articles that included subjects with a diagnosis of dementia according to the DSM IV criteria. The studies were qualitatively assessed using the ADI tool.

resultsThe meta-analysis considered 9 studies that were carried out in Europe between 1993 and 2018 including a total of 18,263 participants, of which 2,137 were diagnosed with dementia. The prevalence rate standardized for age and sex resulted 7.1%. DISCUSSION: This is the first systematic review on the prevalence of dementia in Europe considering only high-quality studies adopting the same diagnostic criteria (i.e., DSM IV).

Indexed as

AgedAged, 80 and overDementiaDiagnostic and Statistical Manual of Mental DisordersEuropeFemaleHumansMalePrevalenceSensitivity and SpecificityDementia epidemiologyprevalence studiessystematic review

Identifiers

PMID30412486
PMCPMC6294583

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.