ArticleJournal of Alzheimer's disease : JAD2018
The Association Between Body Mass Index, and Cognitive, Functional, and Behavioral Declines for Incident Dementia.
Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
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- The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multi-Level Variable Selection Using a BART-Enhanced Mixed-Effects Framework.Statistics in medicine · 2026Article
- The association between medial prefrontal GABA concentration and memory performance is disrupted in human with a high body mass index.Brain imaging and behavior · 2026Article
- Association between cumulative average BMI and cognitive decline: a 24-year cohort study.Journal of neurology · 2026Article
- Reproductive health history and later life cognition in African Caribbean women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Body weight trajectories from midlife are associated with cognitive decline in advanced age.Scientific reports · 2025Article
- Cardiovascular health and its association with dementia, Parkinson's Disease, and mortality among UK older adults.Brain, behavior, & immunity - health · 2025Article
- Habitual caffeine intake, genetics and cognitive performance.Journal of psychopharmacology (Oxford, England) · 2025Article
- Assessing the Biological Mechanisms Linking Smoking Behavior and Cognitive Function: A Mediation Analysis of Untargeted Metabolomics.Metabolites · 2023Article
- Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities.Scientific reports · 2023Article
- Estimating Bidirectional Transitions and Identifying Predictors of Mild Cognitive Impairment.Neurology · 2023Article
- Article
- Relationship Between Vitamin D Status and Brain Perfusion in Neuropsychiatric Lupus.Nuclear medicine and molecular imaging · 2022Article
- Cerebrospinal Fluid Cortisol and Dehydroepiandrosterone Sulfate, Alzheimer's Disease Pathology, and Cognitive Decline.Frontiers in aging neuroscience · 2022Article
- Body Mass Index, Waist Circumference, and Cognitive Decline Among Chinese Older Adults: A Nationwide Retrospective Cohort Study.Frontiers in aging neuroscience · 2022Article
- Association Between Childhood Neighborhood Quality and the Risk of Cognitive Dysfunction in Chinese Middle-Aged and Elderly Population: The Moderation Effect of Body Mass Index.Frontiers in aging neuroscience · 2021Article
- Age of Migration and Cognitive Function Among Older Latinos in the United States.Journal of Alzheimer's disease : JAD · 2020Article
- Glycosylated hemoglobin level, race/ethnicity, and cognition in midlife and early old age.Research in human development · 2020Article
- Impact of the Apolipoprotein E ε4 Allele on Cognition and Omega-3 Fatty Acid Levels in the Plasma Membrane of Red Blood Cells in Healthy Elderly Japanese Population.Dementia and geriatric cognitive disorders extraArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAssociation between high adiposity and the clinical progression of dementia remains puzzling.
objectiveTo separately examine the association between body mass index (BMI) and cognitive, functional, and behavioral declines before, at, and after diagnosis of dementia, and further stratified by age groups, and sex.
methodsA total of 1,141 individuals with incident dementia were identified from the Uniform Data Set of the National Alzheimer's Coordinating Center. Cognitive function was evaluated by Mini-Mental State Exam, functional abilities were assessed using Functional Activities Questionnaire, and behavioral symptoms were captured by Neuropsychiatric Inventory Questionnaire at each follow-up visit. We used separate linear-mixed effects models to examine the association.
resultsCompared to moderate baseline BMI, high baseline BMI was associated with 0.30-point slower annual progression rates in functional decline. For individuals aged 76 and over, high baseline BMI was associated with 0.42-point faster progression rates in cognitive decline annually. A U-shaped association between baseline BMI and cognitive decline was observed among men.
conclusionBMI levels before dementia diagnosis may facilitate the identification of different risk profiles for progression rates of cognitive and functional declines in individuals who developed dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.