ArticleJournal of women's health (2002)2019
Uterine Fibroids and the Risk of Cardiovascular Disease in the Coronary Artery Risk Development in Young Adult Women's Study.
Article in Journal of women's health (2002), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Cardiovascular outcomes after hysterectomy: a systematic review and meta-analysis.Proceedings (Baylor University. Medical Center) · 2026Pooled it
- Investigating the shared genetic architecture of uterine leiomyoma and breast cancer: A genome-wide cross-trait analysis.American journal of human genetics · 2022Pooled it
- Emulating a target trial of surgical removal of uterine fibroids on atherosclerotic cardiovascular disease.Fertility and sterility · 2026Article
- Fibroids and health disparities: the COllaboration for EQuity in Uterine Leiomyomas specialized center.American journal of obstetrics and gynecology · 2026Article
- Association Between Uterine Fibroids and Risk of Atherosclerotic Cardiovascular Disease.Journal of the American Heart Association · 2026Article
- Molecular Impact of Metabolic and Endocrine Disturbance on Endometrial Function in Polycystic Ovary Syndrome.International journal of molecular sciences · 2025Review
- Tailoring cardiovascular risk prediction to females.The Journal of endocrinology · 2025Review
- Causal relationship between uterine fibroids and cardiovascular disease: A two-sample Mendelian randomization study.Medicine · 2025Article
- Impact of Uterine Leiomyomas on Cardiovascular Disease Risk in Young Reproductive-Aged Women: A Nationwide Population-Based Cohort Study.Journal of clinical medicine · 2025Article
- Heart Failure Associated with Giant Uterine Leiomyoma: A Case Report.Medicina (Kaunas, Lithuania) · 2024Article
- Hypertension, Cardiovascular Risk Factors, and Uterine Fibroid Diagnosis in Midlife.JAMA network open · 2024Article
- Association between uterine leiomyoma and fragmented QRS waves: a prospective case-control study.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Uterine leiomyoma causes an increase in systolic blood pressure: a two-sample Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Relationship Among Surgical Fibroid Removal, Blood Pressure, and Biomarkers of Renin-Angiotensin-Aldosterone System Activation.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Therapeutic Carbohydrate Restriction as a Metabolic Modality for the Prevention and Treatment of Abnormal Uterine Bleeding.Nutrients · 2023Article
- Women's Reproductive Milestones and Cardiovascular Disease Risk: A Review of Reports and Opportunities From the CARDIA Study.Journal of the American Heart Association · 2023Review
- Management of Uterine Fibroids and Its Complications During Pregnancy: A Review of Literature.Cureus · 2022Review
- Uterine bleeding: how understanding endometrial physiology underpins menstrual health.Nature reviews. Endocrinology · 2022Review
- Exploring the role of uterine fibroids in promotion of cardiovascular diseases by diabetes exposure: Findings from national health and nutrition examination survey 1999-2006.Frontiers in cardiovascular medicine · 2022Article
- A transcriptome-wide association study of uterine fibroids to identify potential genetic markers and toxic chemicals.PloS one · 2022Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundUterine fibroids, the most common reproductive tract tumor in women, have been associated with hypertension and atherosclerotic cardiovascular disease (CVD). Prior studies of fibroids and CVD have examined the subset of women with symptomatic fibroids who undergo hysterectomy, itself a risk factor for CVD. We aimed to study the risk of subclinical CVD, as determined by coronary artery calcification (CAC), carotid intima media thickness (CIMT), and left ventricular (LV) mass, in women with ultrasound-diagnosed uterine fibroids. MATERIALS AND
methodsParticipants were 972 women from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a cohort recruited in 1985-1986. CARDIA screened black and white women aged 35-49 years by ultrasound for fibroids at 16 years of follow-up (2002-2004). Demographics and CVD risk factors were collected in 2000-2001 at 15 years of follow-up (baseline for this analysis). Women were tested at years 15, 20, and 25 for CAC, at year 20 for CIMT, and at year 25 for echocardiographic LV mass. Multivariable logistic regression was used to estimate the odds of CAC, CIMT, and LV mass.
resultsFifty-two percent of women had fibroids (61.7% in black, 38.3% in white women). Most CVD risk factors were more common in women with fibroids. Adjusted odds of subclinical CVD, such as elevated CIMT and elevated LV mass, were not different for women with fibroids compared with those without (CIMT odds ratio [OR] = 1.03; confidence interval [95% CI] 0.7-1.5 and LV mass OR = 1.14; 95% CI 0.77-1.68), when adjusted for confounders.
conclusionsAlthough women with fibroids had more CVD risk factors, presence of fibroids was not associated with subclinical CVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.