ArticleAmerican journal of physiology. Heart and circulatory physiology2019
Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans.
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Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
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- Photoaged microplastics disrupt endothelial stretch-sensitive ion channels to impair calcium signaling and vascular integrity.bioRxiv : the preprint server for biology · 2026Article
- Bryostatin-1 improves function in arteries with suppressed endothelial cell autophagy.GeroScience · 2026Article
- Optimizing cerebrovascular endothelial health through shear stress modulation.Experimental physiology · 2025Review
- A Novel Function of NaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Autolysosomal Dysfunction in Obesity-induced Metabolic Inflammation and Related Disorders.Current obesity reports · 2025Review
- Autophagy in High-Fat Diet and Streptozotocin-Induced Metabolic Cardiomyopathy: Mechanisms and Therapeutic Implications.International journal of molecular sciences · 2025Review
- Impaired endothelial function contributes to cardiac dysfunction: role of mitochondrial dynamics.American journal of physiology. Heart and circulatory physiology · 2025Review
- Dysfunctional and Dysregulated Nitric Oxide Synthases in Cardiovascular Disease: Mechanisms and Therapeutic Potential.International journal of molecular sciences · 2023Review
- Proteostasis and resilience in the mechanically-stressed vascular endothelium.Current opinion in physiology · 2023Review
- MicroRNA-216a is essential for cardiac angiogenesis.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Activating P2Y1 receptors improves function in arteries with repressed autophagy.Cardiovascular research · 2023Article
- Effect of blood flow-restricted resistance training on myocardial fibrosis in early spontaneously hypertensive rats.Frontiers in cardiovascular medicine · 2023Article
- Autophagy regulates anti-angiogenic property of lenvatinib in thyroid cancer.American journal of cancer research · 2023Article
- Recent Insights Concerning Autophagy and Endothelial Cell Nitric Oxide Generation.Current opinion in physiology · 2022Article
- Adipose stromal vascular fraction reverses mitochondrial dysfunction and hyperfission in aging-induced coronary microvascular disease.American journal of physiology. Heart and circulatory physiology · 2022Article
- Article
- You aren't IMMUNE to the ceramides that accumulate in cardiometabolic disease.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2022Article
- Laminar shear stress inhibits inflammation by activating autophagy in human aortic endothelial cells through HMGB1 nuclear translocation.Communications biology · 2022Article
- The role of autophagy in cardiovascular pathology.Cardiovascular research · 2022Review
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Authors and funding
12 authors at 2 institutions in 1 country.
Seul-Ki ParkDepartment of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.
D Taylor La SalleDepartment of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.
James CerbieDepartment of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.
Jae Min ChoDepartment of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.
Amber BledsoeDepartment of Anesthesiology, University of Utah , Salt Lake City, Utah.
Ashley NelsonGeriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, and Department of Internal Medicine, University of Utah , Salt Lake City, Utah.
David E MorganDepartment of Anesthesiology, University of Utah , Salt Lake City, Utah.
Russell S RichardsonDepartment of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.
Yan-Ting ShiuDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Utah , Salt Lake City, Utah.
Sihem BoudinaDepartment of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.
Joel D TrinityDepartment of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.
J David SymonsDepartment of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.
University of Utah · USGeriatric Research Education and Clinical Center · US
Funding
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MTissue Imaging, Biochemistry and MorphologyP01HL091830 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WAGNER, PETER D · 2009 to 2013
$10.1MWhite Adipose Tissue Physiology, Mitochondrial Function and AdiponectinR01DK099110 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI PHILIPP E SCHERER · 2013 to 2026
$6.7MAutophagy maintains vascular function through a novel glycolysis-linked pathway regulating eNOS.R01HL141540 · NHLBI · UNIVERSITY OF UTAH · PI SYMONS, JOHN DAVID · 2018 to 2021
$1.7MNovel pathways for fat burning that protects from high fat diet-induced metabolicR01DK098646 · NIDDK · UNIVERSITY OF UTAH · PI BOUDINA, SIHEM · 2013 to 2017
$1.6MMechanotransduction in Neointimal Hyperplasia Formation in Arteriovenous GraftsR01DK100505 · NIDDK · UNIVERSITY OF UTAH · PI SHIU, YAN-TING E. · 2014 to 2017
$1.3MCharacterizing the phenotype of young and old mice with disrupted vascular autophagyR03AG052848 · NIA · UNIVERSITY OF UTAH · PI SYMONS, JOHN DAVID · 2017 to 2018
$152kUnderstanding the Exercise-Hypertension Paradox: Implication for RehabilitationIK2RX001215 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI TRINITY, JOEL DOUGLAS · 2014 to 2018
–BLRD VA I01 BX004133NHLBI NIH HHS P01 HL091830NHLBI NIH HHS R01 HL141540NIA NIH HHS R03 AG052848NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK098646NIDDK NIH HHS R01 DK099110NIDDK NIH HHS R01 DK100505RRD VA IK2 RX001215
Abstract
Continuous laminar shear stress increases the process of autophagy, activates endothelial nitric oxide (NO) synthase phosphorylation at serine 1177 (p-eNOS
Indexed as
AutophagyExerciseAdultArteriesCells, CulturedEndothelial CellsEndothelium, VascularHand StrengthHumansMaleNitric OxideNitric Oxide Synthase Type IIINitric OxideNitric Oxide Synthase Type IIIblood vesselexerciseimmunofluorescenceshear stress
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Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.