Evidence map›Paper›PMID 30412392›Full record

ArticleChemical research in toxicology2018

Oxidation of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Leads to Substantial DNA-Histone Cross-Links within Nucleosome Core Particles.

Jing Bai, Yingqian Zhang, Zhen Xi, Marc M Greenberg, Chuanzheng Zhou

Abstract read
In one paragraph

Article in Chemical research in toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Generation of Recombinant Nucleosomes Containing Site-Specific DNA Damage.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. A Photosensitized Singlet Oxygen (Molecules (Basel, Switzerland) · 2022
    Review
  10. Targeting DNA-Protein CrosslinksFrontiers in molecular biosciences · 2022
    Review
  11. Article
  12. Article
  13. (De)Toxifying the Epigenetic Code.Chemical research in toxicology · 2019
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jing BaiState Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.
Yingqian ZhangState Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.
Zhen XiState Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.ORCID 0000-0002-3332-5413
Marc M GreenbergDepartment of Chemistry , Johns Hopkins University , 3400 N. Charles Street , Baltimore , Maryland 21218 , United States.ORCID 0000-0002-5786-6118
Chuanzheng ZhouState Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.ORCID 0000-0002-0811-7794
Nankai University · CNJohns Hopkins University · US

Funding

Repair, Replication, and Detection of Oxidatively Damaged DNAR01GM063028 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREENBERG, MARC M · 2002 to 2018
$5.4M
NIGMS NIH HHS R01 GM063028
6 · The paper itself

Abstract

8-Oxo-7,8-dihydro-2'-deoxyguanosine(8-oxodGuo) is a common primary product of cellular oxidative DNA damage. 8-OxodGuo is more readily oxidized than 2'-deoxyguanosine (dG); a two-electron oxidation generates a highly reactive intermediate (OG

Indexed as

8-Hydroxy-2'-DeoxyguanosineDeoxyguanosineDNADNA DamageEthylaminesFerricyanidesHistonesKineticsNucleosomesOxidation-ReductionPiperidines8-Hydroxy-2'-DeoxyguanosineDeoxyguanosineDNAethylamineEthylaminesFerricyanideshexacyanoferrate IIIHistonesNucleosomespiperidinePiperidines

Identifiers

PMID30412392
PMCPMC6425731
OpenAlexW2900376084

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.