ArticleeLife2018
Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the
Open access · goldAbstract read
In one paragraph
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 51 citations in OpenAlex.
- Metabolic Programming of β-Cell Fate, State, and Function through Time and Space.Physiology (Bethesda, Md.) · 2026Review
- Coordinated expression and assembly of BiP, p58Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Polyadenylation of insulin mRNA by Tent5a regulates pancreatic beta cells.Nature communications · 2026Article
- Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis.Diabetes · 2026Article
- The Genetic Landscape of Diabetes Mellitus: Lessons from Monogenic and Polygenic Forms.Life (Basel, Switzerland) · 2026Review
- Review
- Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells.Nature reviews. Endocrinology · 2025Review
- Multiple low dose streptozotocin-induced diabetes as a model for studying autoimmune diabetes in humans.Animal models and experimental medicine · 2025Review
- Renalase inhibition defends against acute and chronic β cell stress by regulating cell metabolism.Molecular metabolism · 2025Article
- Diuretics: a review of the pharmacology and effects on glucose homeostasis.Frontiers in pharmacology · 2025Review
- β Cell Stress and Endocrine Function During T1D: What Is Next to Discover?Endocrinology · 2023Article
- VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling.Cell discovery · 2023Article
- Beta cell endoplasmic reticulum stress drives diabetes in the KINGS mouse without causing mass beta cell loss.Diabetic medicine : a journal of the British Diabetic Association · 2022Review
- Macrophages and neutrophils are necessary for ER stress-induced β cell loss.Cell reports · 2022Article
- Aberrant Splicing ofInternational journal of molecular sciences · 2022Article
- Genetic Reduction of Glucose Metabolism Preserves Functional β-Cell Mass in KATP-Induced Neonatal Diabetes.Diabetes · 2022Article
- Insulin Null β-cells Have a Prohormone Processing Defect That Is Not Reversed by AAV Rescue of Proinsulin Expression.Endocrinology · 2022Article
- Review
- Article
- The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice.Diabetologia · 2022Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Yael RiahiThe Endocrine Service, The Hebrew University-Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.
Tal IsraeliThe Endocrine Service, The Hebrew University-Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0001-9293-0827
Roni YeroslavizThe Endocrine Service, The Hebrew University-Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.
Shoshana ChimenezThe Endocrine Service, The Hebrew University-Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.
Dana AvrahamiThe Endocrine Service, The Hebrew University-Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.
Miri Stolovich-RainDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ido AlterThe Endocrine Service, The Hebrew University-Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.
Marina SebagThe Endocrine Service, The Hebrew University-Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.
Nava PolinThe Endocrine Service, The Hebrew University-Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ernesto Bernal-MizrachiDepartment of Internal Medicine, Division of Endocrinology, Metabolism and Diabetes, Miller School of Medicine, University of Miami, Miami, United States.
Yuval DorDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Erol CerasiThe Endocrine Service, The Hebrew University-Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0002-8234-3618
Gil LeibowitzThe Endocrine Service, The Hebrew University-Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0002-6915-4361
Hebrew University of Jerusalem · ILUniversity of Miami · US
Funding
AKT/mTOR Signaling and Regulation of Cell Cycle in beta CellsR01DK073716 · NIDDK · WASHINGTON UNIVERSITY · PI BERNAL-MIZRACHI, ERNESTO · 2006 to 2022
$4.6MNutrient Signals and Programming of Pancreas DevelopmentR01DK084236 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERNAL-MIZRACHI, ERNESTO · 2010 to 2018
$2.9MmTOR signaling and regulation of alpha-cell mass and functionI01BX002728 · VA · MIAMI VA HEALTH CARE SYSTEM · PI BERNAL-MIZRACHI, ERNESTO · 2016 to 2025
–BLRD VA I01 BX002728NIDDK NIH HHS R01 DK073716NIDDK NIH HHS R01 DK084236
Abstract
Unresolved ER stress followed by cell death is recognized as the main cause of a multitude of pathologies including neonatal diabetes. A systematic analysis of the mechanisms of β-cell loss and dysfunction in
Indexed as
AnimalsAnimals, NewbornApoptosisDiabetes MellitusEndoplasmic ReticulumEndoplasmic Reticulum StressHumansInsulin-Secreting CellsMechanistic Target of Rapamycin Complex 1MiceMutationProinsulinProtein FoldingMechanistic Target of Rapamycin Complex 1ProinsulinBeta cellsdiabetesER stresshuman biologymedicinemousemTORproinsulin misfoldingproliferation
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What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.