Evidence map›Paper›PMID 30412049›Full record

ArticleeLife2018

Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression.

C Matthew Hope, Jemma L Webber, Sherzod A Tokamov, Ilaria Rebay

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Sticky, Adaptable, and Many-sided: SAM protein versatility in normal and pathological hematopoietic states.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

C Matthew HopeDepartment of Biochemistry and Molecular Biophysics, University of Chicago, Chicago, United States.
Jemma L WebberBen May Department for Cancer Research, University of Chicago, Chicago, United States.
Sherzod A TokamovCommittee on Development, Regeneration, and Stem Cell Biology, University of Chicago, Chicago, United States.
Ilaria RebayBen May Department for Cancer Research, University of Chicago, Chicago, United States.ORCID 0000-0002-2444-3864
University of Chicago · US

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
Molecular And Cellular Biology Training ProgramT32GM007183 · NIGMS · UNIVERSITY OF CHICAGO · PI GLICK, BENJAMIN S, RICE, PHOEBE A · 1985 to 2021
$23.9M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
MULTIDISCIPLINARY CARDIAC SCIENCEST32HL007381 · NHLBI · UNIVERSITY OF CHICAGO · PI JEANNE M DECARA, Yoav Gilad · 1985 to 2026
$12.5M
Function and Regulation of the ETS Transcriptional Repressor Tel-1/YANR01GM080372 · NIGMS · UNIVERSITY OF CHICAGO · PI REBAY, ILARIA · 2007 to 2022
$3.9M
NCI NIH HHS P30 CA014599NHLBI NIH HHS T32 HL007381NIGMS NIH HHS R01 GM080372NIGMS NIH HHS T32 GM007183NIH HHS 2T32 HL007381-36A1NIH HHS P30 CA014599NIH HHS P40 OD018537NIH HHS R01 GM080372NIH HHS T32 GM007183
6 · The paper itself

Abstract

During development, transcriptional complexes at enhancers regulate gene expression in complex spatiotemporal patterns. To achieve robust expression without spurious activation, the affinity and specificity of transcription factor

Indexed as

PolymerizationAllelesAnimalsCell LineageCell NucleusDNADrosophila melanogasterDrosophila ProteinsEye ProteinsModels, BiologicalMutagenesisMutationPhotoreceptor Cells, InvertebrateProtein AggregatesProtein BindingRepressor ProteinsAOP protein, DrosophilaDNADrosophila ProteinsEye ProteinsProtein AggregatesRepressor ProteinsTranscription Factorscomputational biologydevelopmental biologyD. melanogasterETS repressoreye developmentmathematical modelingphotoreceptorreceptor tyrosine kinase signalingsystems biology

Identifiers

PMID30412049
PMCPMC6226293
OpenAlexW2899617802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.