Evidence map›Paper›PMID 30412045›Full record

ArticleTissue engineering. Part A2019

Long-Term Cryopreservation and Revival of Tissue-Engineered Skeletal Muscle.

Lauren Grant, Ritu Raman, Caroline Cvetkovic, Meghan C Ferrall-Fairbanks, Gelson J Pagan-Diaz, Pierce Hadley, Eunkyung Ko, Manu O Platt, Rashid Bashir

Open access · greenAbstract read
In one paragraph

Article in Tissue engineering. Part A, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  5. Review
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  7. Review
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  9. Biohybrid Design Gets Personal: New Materials for Patient-Specific Therapy.Advanced materials (Deerfield Beach, Fla.) · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Lauren Grant1Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Ritu Raman3Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Caroline Cvetkovic1Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Meghan C Ferrall-Fairbanks4Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.
Gelson J Pagan-Diaz1Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Pierce Hadley1Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Eunkyung Ko1Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Manu O Platt4Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.
Rashid Bashir1Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.
University of Illinois Urbana-Champaign · USThe Wallace H. Coulter Department of Biomedical Engineering · USIllinois College · USMassachusetts Institute of Technology · US

Funding

Tissue microenvironment (TIMe) training programT32EB019944 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BHARGAVA, ROHIT, GASKINS, REX · 2016 to 2025
$1.9M
NIBIB NIH HHS T32 EB019944
6 · The paper itself

Abstract

impact statementThe ability to freeze, revive, and prolong the lifetime of tissue-engineered skeletal muscle without incurring any loss of function represents a significant advancement in the field of tissue engineering. Cryopreservation enables the efficient fabrication, storage, and shipment of these tissues. This in turn facilitates multidisciplinary collaboration between research groups, enabling advances in skeletal muscle regenerative medicine, organ-on-a-chip models of disease, drug testing, and soft robotics. Furthermore, the observation that freezing undifferentiated skeletal muscle enhances functional performance may motivate future studies developing stronger and more clinically relevant engineered muscle.

Indexed as

CryopreservationAnimalsBiomechanical PhenomenaCell DifferentiationCell LineCell SurvivalExtracellular MatrixFreezingLeucineMiceMuscle Fibers, SkeletalMuscle, SkeletalProteolysisTime FactorsTissue EngineeringE 64Leucinebioactuatorbiobotcryopreservationcysteine cathepsinsskeletal muscletissue engineering

Identifiers

PMID30412045
PMCPMC6916121
OpenAlexW2899689944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.