Evidence map›Paper›PMID 30412002›Full record

ArticleEpigenetics2018

DNA methylation in blood as a mediator of the association of mid-childhood body mass index with cardio-metabolic risk score in early adolescence.

Jian V Huang, Andres Cardenas, Elena Colicino, C Mary Schooling, Sheryl L Rifas-Shiman, Golareh Agha, Yinan Zheng, Lifang Hou, Allan C Just, Augusto A Litonjua and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Speeding up interval estimation forbioRxiv : the preprint server for biology · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Recent progress in epigenetics of obesity.Diabetology & metabolic syndrome · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Gene-based mediation analysis in epigenetic studies.Briefings in bioinformatics · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jian V Huanga Department of Environmental Health Sciences , Columbia Mailman School of Public Health , NY , NY , USA.
Andres Cardenasc Department of Population Medicine , Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston , MA , USA.
Elena Colicinod Department of Environmental Medicine & Public Health , Icahn School of Medicine at Mount Sinai , New York , NY , USA.
C Mary Schoolingb School of Public Health, Li Ka Shing Faculty of Medicine , The University of Hong Kong , Hong Kong SAR , People's Republic of China.
Sheryl L Rifas-Shimanc Department of Population Medicine , Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston , MA , USA.
Golareh Aghaa Department of Environmental Health Sciences , Columbia Mailman School of Public Health , NY , NY , USA.
Yinan Zhengf Center for Population Epigenetics, Feinberg School of Medicine, Northwestern University , Chicago , IL , USA.
Lifang Houg Department of Preventive Medicine, Feinberg School of Medicine , Northwestern University , Chicago , IL , USA.
Allan C Justd Department of Environmental Medicine & Public Health , Icahn School of Medicine at Mount Sinai , New York , NY , USA.ORCID http://orcid.org/0000-0003-4312-5957
Augusto A Litonjuah Division of Pediatric Pulmonary Medicine, Department of Pediatrics , University of Rochester Medical Center , Rochester , NY , USA.ORCID http://orcid.org/0000-0003-0422-5875
Dawn L DeMeoi Channing Division of Network Medicine , Brigham and Women's Hospital , Boston , MA , USA.
Xihong Linl Department of Biostatistics, Harvard T.H. Chan School of Public Health , Harvard University , Boston , MA , USA.
Emily Okenc Department of Population Medicine , Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston , MA , USA.
Marie-France Hivertc Department of Population Medicine , Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston , MA , USA.
Andrea A Baccarellia Department of Environmental Health Sciences , Columbia Mailman School of Public Health , NY , NY , USA.

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven N. Chillrud · 1998 to 2026
$44.7M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUG3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI KLEINMAN, KENNETH P., OKEN, EMILY · 2016 to 2017
$4.1M
Early Life DNA Methylation and Childhood Allergic DiseaseR01HL111108 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L · 2013 to 2016
$3.0M
Novel Epigenomic Biomarkers of Prenatal Risk Factors, and Childhood ObesityR01NR013945 · NINR · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2013 to 2015
$1.6M
Prenatal Exposure to Endocrine Disrupters, DNA Methylation, and Childhood ObesityR00ES023450 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JUST, ALLAN C. · 2016 to 2018
$747k
NHLBI NIH HHS R01 HL111108NICHD NIH HHS R01 HD034568NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R00 ES023450NIH HHS UG3 OD023286NIH HHS UH3 OD023286NINR NIH HHS R01 NR013945
6 · The paper itself

Abstract

Obesity is associated with higher cardio-metabolic risk even in childhood and adolescence; whether this association is mediated by epigenetic mechanisms remains unclear. We examined the extent to which mid-childhood body mass index (BMI) z-score (median age 7.7 years) was associated with cardio-metabolic risk score in early adolescence (median age 12.9 years) via mid-childhood DNA methylation among 265 children in the Project Viva. We measured DNA methylation in leukocytes using the Infinium Human Methylation450K BeadChip. We assessed mediation CpG-by-CpG using epigenome-wide association analyses, high-dimensional mediation analysis, and natural effect models. We observed mediation by mid-childhood DNA methylation at 6 CpGs for the association between mid-childhood BMI z-score and cardio-metabolic risk score in early adolescence in the high-dimensional mediation analysis (accounting for 10% of the total effect) and in the natural effect model (β = 0.04,

Indexed as

BMIcardio-metabolicDNA methylationepigeneticsmediationObesity

Identifiers

PMID30412002
PMCPMC6342073

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.