Evidence map›Paper›PMID 30411843›Full record

ArticleMolecular ecology2018

A fast-evolving X-linked duplicate of importin-α2 is overexpressed in sex-ratio drive in Drosophila neotestacea.

Kathleen E Pieper, Robert L Unckless, Kelly A Dyer

Open access · greenAbstract read
In one paragraph

Article in Molecular ecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Supergene potential of a selfish centromere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  5. Article
  6. TheeLife · 2020
    Article
  7. Article
  8. Article
  9. TheeLife · 2019
    Article
  10. Article
  11. Meiotic drive mechanisms: lessons fromProceedings. Biological sciences · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kathleen E PieperDepartment of Genetics, University of Georgia, Athens, Georgia.
Robert L UncklessDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas.
Kelly A DyerDepartment of Genetics, University of Georgia, Athens, Georgia.ORCID 0000-0001-7480-2055
University of Georgia · USUniversity of Kansas · US

Funding

T32 Predoctoral training grant in geneticsT32GM007103 · NIGMS · UNIVERSITY OF GEORGIA (UGA) · PI DYER, KELLY A · 1985 to 2021
$5.9M
Antimicrobial peptides as models for the evolution of gene duplicationR00GM114714 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI UNCKLESS, ROBERT L · 2016 to 2018
$732k
Division of Environmental Biology 1149350Division of Environmental Biology 1457707National Science Foundation 1149350National Science Foundation 1457707NIGMS NIH HHS R00 GM114714NIGMS NIH HHS R00GM114714NIGMS NIH HHS T32 GM007103NIGMS NIH HHS T32GM007103NIH HHS R00GM114714NIH HHS T32GM007103Society for the Study of EvolutionUniversity of Georgia
6 · The paper itself

Abstract

Selfish genetic elements that manipulate gametogenesis to achieve a transmission advantage are known as meiotic drivers. Sex-ratio X chromosomes (SR) are meiotic drivers that prevent the maturation of Y-bearing sperm in male carriers to result in the production of mainly female progeny. The spread of an SR chromosome can affect host genetic diversity and genome evolution, and can even cause host extinction if it reaches sufficiently high prevalence. Meiotic drivers have evolved independently many times, though only in a few cases is the underlying genetic mechanism known. In this study we use a combination of transcriptomics and population genetics to identify widespread expression differences between the standard (ST) and sex-ratio (SR) X chromosomes of the fly Drosophila neotestacea. We found the X chromosome is enriched for differentially expressed transcripts and that many of these X-linked differentially expressed transcripts had elevated K

Indexed as

Genes, X-LinkedSex Ratioalpha KaryopherinsAnimalsDrosophilaDrosophila ProteinsEvolution, MolecularFemaleGenetics, PopulationMaleRepetitive Sequences, Nucleic AcidSelection, GeneticTranscriptomealpha KaryopherinsDrosophila Proteinskaryopherin alpha 2genetic conflictmeiotic drivenuclear transportspermatogenesistestes

Identifiers

PMID30411843
PMCPMC6312747
OpenAlexW2898392482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.