ArticleJournal of clinical laboratory analysis2019
Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension.
Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Accelerated epigenetic age in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Pooled it
- The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke.Bosnian journal of basic medical sciences · 2021Article
- Roles and Mechanisms of DNA Methylation in Vascular Aging and Related Diseases.Frontiers in cell and developmental biology · 2021Review
- Significant association between DHFR promoter methylation and ischemic stroke in a Chinese hypertensive population.Journal of clinical laboratory analysis · 2020Article
- Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Article
- Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension.Journal of clinical laboratory analysis · 2019Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundSerine hydroxymethyltransferase 1 (SHMT1) is an enzyme involved in folic acid metabolism and is known to contribute to the development of hypertension. We evaluated the relationship between SHMT1 promoter methylation and essential hypertension (EH).
methodsQuantitative methylation-specific polymerase chain reaction was used to measure the SHMT1 promoter methylation level in 241 EH patients and 288 age- and gender-matched healthy individuals. The diagnostic value of SHMT1 promoter hypermethylation was analyzed using a receiver operating characteristic (ROC) curve. The Gene Expression Omnibus (GEO) database and dual-luciferase reporter assay were used to validate our findings.
resultsCompared with the control group, significant differences in SHMT1 promoter methylation were found in both EH and hyperhomocysteinemia groups (P < 0.001 and P = 0.029, respectively). The area under the curve of the diagnosis of SHMT1 promoter hypermethylation for EH was 0.808, with a sensitivity and specificity of 73.9% and 77.8%, respectively. The risk of SHMT1 promoter hypermethylation was significantly higher in the >65-year group than in the ≤65-year group (odds ratio = 3.925; 95% confidence interval = 2.141-7.196). In addition, GEO database analysis showed that 5-aza-deoxycytidine increased gene expression in several carotid endothelial cell lines. A dual-luciferase reporter assay revealed that the target sequence in the SHMT1 promoter upregulated gene expression.
conclusionOur findings indicate that SHMT1 promoter hypermethylation increases the risk of EH and may be a promising biomarker for EH.
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