Evidence map›Paper›PMID 30411792›Full record

ArticleInternational journal of cancer2019

Circulating 25-hydroxyvitamin D, vitamin D binding protein and risk of advanced and lethal prostate cancer.

Chen Yuan, Irene M Shui, Kathryn M Wilson, Meir J Stampfer, Lorelei A Mucci, Edward L Giovannucci

Open access · bronzeAbstract read
In one paragraph

Article in International journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. The double disparity: Vitamin D deficiency and lethal prostate cancer in black men.The Journal of steroid biochemistry and molecular biology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. The role of nutritional interventions in prostate cancer: A review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021
    Review
  12. Article
  13. Article
  14. The Association of a Novel IdentifiedCancer genomics & proteomics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chen YuanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.ORCID 0000-0002-0708-9648
Irene M ShuiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Kathryn M WilsonDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Meir J StampferDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Lorelei A MucciDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Edward L GiovannucciDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Brigham and Women's Hospital · USHarvard University · US

Funding

Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Energy Balance-Related Hormones & Prostate Cancer Incidence & ProgressionR01CA133891 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI GIOVANNUCCI, EDWARD · 2008 to 2012
$3.3M
Growth Factors and Lethal Prostate Cancer SignatureR01CA141298 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI STAMPFER, MEIR · 2010 to 2013
$2.2M
NCI NIH HHS R01 CA133891NCI NIH HHS R01 CA141298NCI NIH HHS T32 CA009001NCI NIH HHS U01 CA167552NIH HHS R01CA133891NIH HHS R01CA141298NIH HHS T32CA09001NIH HHS U01CA167552
6 · The paper itself

Abstract

We previously found that higher total 25-hydroxyvitamin D [25(OH)D] levels were associated with lower risk of lethal prostate cancer. However, the relationships of bioavailable 25(OH)D and vitamin D binding protein (VDBP) with risk of advanced and lethal prostate cancer are unclear. In a prospective case-control study of 156 pairs of advanced prostate cancer cases and controls, we directly measured prediagnostic circulating 25(OH)D and VDBP and calculated bioavailable 25(OH)D using a validated formula. We examined the association of bioavailable 25(OH)D and VDBP levels with risk of advanced and lethal prostate cancer and whether total 25(OH)D levels interacted with VDBP levels to affect the risk. Conditional logistic models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Compared to total 25(OH)D (p

Indexed as

AdultAgedBiological AvailabilityCase-Control StudiesFollow-Up StudiesHumansLogistic ModelsMaleMiddle AgedOdds RatioProspective StudiesProstateProstatic NeoplasmsRisk FactorsVitamin DVitamin D-Binding Protein25-hydroxyvitamin DVitamin DVitamin D-Binding Protein25-hydroxyvitamin Dfree hormone hypothesisprostate cancervitamin D binding protein

Identifiers

PMID30411792
PMCPMC7211036
OpenAlexW2899980056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.