Evidence map›Paper›PMID 30411529›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology2019

Physical, chemical, and synthetic virology: Reprogramming viruses as controllable nanodevices.

Maria Yanqing Chen, Susan S Butler, Weitong Chen, Junghae Suh

Open access · greenAbstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Advances in Synthetic Biology and Biosafety Governance.Frontiers in bioengineering and biotechnology · 2021
    Review
  10. Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Maria Yanqing ChenDepartment of Bioengineering, Rice University, Houston, Texas.
Susan S ButlerDepartment of Bioengineering, Rice University, Houston, Texas.
Weitong ChenDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, Texas.
Junghae SuhDepartment of Bioengineering, Rice University, Houston, Texas.
Rice University · US

Funding

Targeted Gene Therapy of Heart Failure Post Myocardial InfarctionR01HL138126 · NHLBI · RICE UNIVERSITY · PI BAO, GANG, SUH, JUNGHAE · 2018 to 2021
$2.0M
Provectors for treatment of ovarian cancerR01CA207497 · NCI · RICE UNIVERSITY · PI BAO, GANG, SUH, JUNGHAE · 2016 to 2020
$1.8M
NCI NIH HHS R01 CA207497NHLBI NIH HHS R01 HL138126NIH HHS R01CA207497NIH HHS R01HL138126
6 · The paper itself

Abstract

The fields of physical, chemical, and synthetic virology work in partnership to reprogram viruses as controllable nanodevices. Physical virology provides the fundamental biophysical understanding of how virus capsids assemble, disassemble, display metastability, and assume various configurations. Chemical virology considers the virus capsid as a chemically addressable structure, providing chemical pathways to modify the capsid exterior, interior, and subunit interfaces. Synthetic virology takes an engineering approach, modifying the virus capsid through rational, combinatorial, and bioinformatics-driven design strategies. Advances in these three subfields of virology aim to develop virus-based materials and tools that can be applied to solve critical problems in biomedicine and biotechnology, including applications in gene therapy and drug delivery, diagnostics, and immunotherapy. Examples discussed include mammalian viruses, such as adeno-associated virus (AAV), plant viruses, such as cowpea mosaic virus (CPMV), and bacterial viruses, such as Qβ bacteriophage. Importantly, research efforts in physical, chemical, and synthetic virology have further unraveled the design principles foundational to the form and function of viruses. This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Biology-Inspired Nanomaterials > Protein and Virus-Based Structures.

Indexed as

NanomedicineNanostructuresSynthetic BiologyVirologyVirusesAnimalsCells, CulturedChemical PhenomenaDependovirusGenetic TherapyHumansMiceadeno-associated viruschemical virologygene therapyphysical virologysynthetic virology

Identifiers

PMID30411529
PMCPMC6461522
OpenAlexW2900410223

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.