ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019
Quality of Life for 19,114 participants in the ASPREE (ASPirin in Reducing Events in the Elderly) study and their association with sociodemographic and modifiable lifestyle risk factors.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Prescription and Non-prescription Medication Pill Burdens and Their Associations with Health-Related Quality of Life in Older Adults: A Cross-Sectional Study.Drugs & aging · 2025Trial
- Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial.Molecular psychiatry · 2021Trial
- Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial.JAMA psychiatry · 2020Trial
- Translation and Psychometric Properties of the Persian Version of the Older Adult Lifestyle Scale.Health science reports · 2026Article
- Health-related quality of life and associated factors among people with disabilities in Northwest Ethiopia.Scientific reports · 2025Article
- Incidence of major health events across metropolitan and regional areas: A 10+ year prospective study of 16,697 older Australians.Australasian journal on ageing · 2025Observational
- Advances in Understanding Lipopolysaccharide-Mediated Hepatitis: Mechanisms and Pathological Features.Current issues in molecular biology · 2025Review
- Childcare engagement among older adults in Australia and subsequent physical, psychosocial, and behavioral health outcomes.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- The association between adverse events in later life and mortality in older individuals.Comprehensive psychoneuroendocrinology · 2023Article
- Potentially inappropriate medication use is associated with increased risk of incident disability in healthy older adults.Journal of the American Geriatrics Society · 2023Article
- Functional outcomes following knee replacement in community-dwelling older adults.BMC geriatrics · 2023Article
- Spanish validation of the simple lifestyle indicator questionnaire: validity and reliability analysis.Frontiers in public health · 2023Article
- Sleep-disordered breathing was associated with lower health-related quality of life and cognitive function in a cross-sectional study of older adults.Respirology (Carlton, Vic.) · 2022Article
- Functional Outcomes Following Hip Replacement in Community-Dwelling Older Adults.Journal of clinical medicine · 2022Article
- Impact of economic factors, social health and stressful life events on physical health-related quality of life trajectories in older Australians.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Trajectories of depressive symptoms in older adults and associated health outcomes.Nature aging · 2022Article
- Trajectories of physical health-related quality of life and the risk of incident cardiovascular disease events and all-cause mortality in older people.American heart journal plus : cardiology research and practice · 2022Article
- The role of health-related quality of life in risk prediction for developing cardiovascular disease, dementia and all-cause death among general older adults.Frontiers in public health · 2022Article
- Health-related quality of life and incident cardiovascular disease events in community-dwelling older people: A prospective cohort study.International journal of cardiology · 2021Article
- Health-related quality of life and all-cause mortality among older healthy individuals in Australia and the United States: a prospective cohort study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
purposeTo explore the relationship between sociodemographic and lifestyle variables with health-related quality of life (HRQoL) of a large cohort of 'healthy' older individuals.
methodsThe sample included individuals aged 65+ years from Australia (N = 16,703) and the USA (N = 2411) enrolled in the ASPirin in Reducing Events in the Elderly (ASPREE) multicentre placebo-controlled trial study and free of cardiovascular disease, dementia, serious physical disabilities or 'fatal' illnesses. The associations with the physical (PCS) and mental component scores (MCS) of HRQoL (SF-12 questionnaire) were explored using multiple linear regression models from data collected at baseline (2010-2014).
resultsThe adjusted PCS mean was slightly higher in the USA (49.5 ± 9.1) than Australia (48.2 ± 11.6; p < 0.001), but MCS was similar in both samples (55.7 ± 7.5 and 55.7 ± 9.6, respectively; p = 0.603). Males, younger participants, better educated, more active individuals, or those currently drinking 1-2 alcoholic drinks/day showed a better HRQoL (results more evident for PCS than MCS), while current heavy smokers had the lowest physical HRQoL in both countries. Neither age, walking time, nor alcohol intake was associated with MCS in either cohort.
conclusionsBaseline HRQoL of ASPREE participants was higher than that reported in population-based studies of older individuals, but the associations between sociodemographic and lifestyle variables were consistent with the published literature. As the cohort ages and develops chronic diseases, ASPREE will be able to document HRQoL changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.