ArticleACS omega2018
Aggregation-Induced Emission-Based Fluorescence Probe for Fast and Sensitive Imaging of Formaldehyde in Living Cells.
Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine.Chemical reviews · 2024Review
- Fluorescent Sensor Based on 1Molecules (Basel, Switzerland) · 2024Article
- Recent Progress in the Development of Organic Chemosensors for Formaldehyde Detection.ACS omega · 2023Review
- Approaches to Formaldehyde Measurement: From Liquid Biological Samples to Cells and Organisms.International journal of molecular sciences · 2022Review
- Systematic investigation of the aza-Cope reaction for fluorescence imaging of formaldehydeChemical science · 2021Article
- N, P-co-doped carbon dots as a dual-mode colorimetric/ratiometric fluorescent sensor for formaldehyde and cell imaging via an aminal reaction-induced aggregation process.Mikrochimica acta · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Formaldehyde (FA), as a reactive carbonyl species and signaling molecule, plays an important role in living systems. Here, an FA-responsive probe with fast response and great selectivity is designed based on aggregation-induced emission. The probe is prepared by functionalizing tetraphenylethene (TPE) with two amine groups. FA is detected based on the solubility differences between the amine-functionalized TPE and the corresponding Schiff bases after reaction with FA. The probe exhibits a limit of detection of 40 nM and a response time of ∼90 s. Furthermore, its ability to detect both endogenous and exogenous FA is demonstrated in living cells with high specificity. Moreover, the probe is also introduced to image endogenous FA in real time with fast response. These results suggest that our probe holds great potential for tracking FA in living systems under various physiological conditions as well as related biomedical applications.
Identifiers
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Registered trials
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