ArticleLaryngoscope investigative otolaryngology2018
Oral L-thyroxine liquid versus tablet in patients submitted to total thyroidectomy for thyroid cancer (without malabsorption): A prospective study.
Article in Laryngoscope investigative otolaryngology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Comparison of tablet versus liquid ethanol-free Levothyroxine in thyroidectomised patients.Endocrine · 2025Article
- Levothyroxine therapy in thyroidectomized patients: ongoing challenges and controversies.Frontiers in endocrinology · 2025Review
- Levothyroxine dose prediction post-thyroidectomy for differentiated thyroid carcinoma.Frontiers in endocrinology · 2025Article
- Hypothyroidism and metabolic cardiovascular disease.Frontiers in endocrinology · 2024Review
- Liquid L-T4 therapy in hypothyroid patients with gastric diseases, an observational study.Frontiers in endocrinology · 2024Observational
- Efficacy and safety of postoperative levothyroxine sodium tablets for improving serum thyroid hormone levels and tumor marker levels in patients with thyroid tumors.European journal of translational myology · 2023Article
- Seeking optimization of LT4 treatment in patients with differentiated thyroid cancer.Hormones (Athens, Greece) · 2022Review
- Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption.Frontiers in endocrinology · 2022Review
- Improvements in Quality of Life and Thyroid Parameters in Hypothyroid Patients on Ethanol-Free Formula of Liquid Levothyroxine Therapy in Comparison to Tablet LT4 Form: An Observational Study.Journal of clinical medicine · 2021Article
- The Stability of TSH, and Thyroid Hormones, in Patients Treated With Tablet, or Liquid Levo-Thyroxine.Frontiers in endocrinology · 2021Review
- Editorial: Levothyroxine Therapy in Patients With Hypothyroidism.Frontiers in endocrinology · 2021Article
- L-T4 Therapy in Enteric Malabsorptive Disorders.Frontiers in endocrinology · 2021Review
- Review
- Levothyroxine Therapy in Thyrodectomized Patients.Frontiers in endocrinology · 2020Review
- Liquid and softgel capsules of l-thyroxine results lower serum thyrotropin levels more than tablet formulations in hypothyroid patients.Journal of clinical & translational endocrinology · 2019Article
- Review
- Total or Near-total Thyroidectomy in treatment of Thyroid Cancer.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNo consistent data are present in literature about the effectiveness of Levothyroxine (L-T4) liquid formulation in patients without malabsorption after thyroidectomy. The aim of this study is to compare the effectiveness of L-T4 liquid formulation, with L-T4 tablets, in thyroid cancer patients after thyroidectomy (without malabsorption or drug interference).
methodsOne hundred five patients were recruited; 52 patients were treated with liquid L-T4 formulation, while 53 with L-T4 tablets, at the same dosage (1.5 mcg/kg/day). Patients started to assume the drug the day after surgery, 30 min before breakfast. In both groups circulating levels of thyrotropic hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were dosed at week 6 (first control), and then at week 12 (second control).
resultsWe obtained significantly lower TSH values in the liquid L-T4 group patients, compared to the tablet L-T4 group, at the first control (
conclusionsA better control of TSH was observed in thyroidectomized patients (without malabsorption, gastric disorders, or drug interference) with liquid L-T4 regimen. LEVEL OF EVIDENCE: 2c-Outcomes Research.
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