ArticleEye and vision (London, England)2018
Microvascular blood flow velocities measured with a retinal function imager: inter-eye correlations in healthy controls and an exploration in multiple sclerosis.
Article in Eye and vision (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Reliability of Optical Coherence Tomography Angiography Retinal Blood Flow Analyses.Translational vision science & technology · 2023Observational
- Subretinal fluid disturbs the retinal venous blood flow in central serous chorioretinopathy.Scientific reports · 2022Article
- Exploratory study of non-invasive, high-resolution functional macular imaging in subjects with diabetic retinopathy.International journal of ophthalmology · 2021Article
- Retinal Oxygen Metabolism and Haemodynamics in Patients With Multiple Sclerosis and History of Optic Neuritis.Frontiers in neuroscience · 2021Article
- Retinal blood flow in critical illness and systemic disease: a review.Annals of intensive care · 2020Review
- Alterations in the retinal vasculature occur in multiple sclerosis and exhibit novel correlations with disability and visual function measures.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Article
- Retinal Tissue Perfusion in Patients with Multiple Sclerosis.Current eye research · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe retinal microcirculation has been studied in various diseases including multiple sclerosis (MS). However, inter-eye correlations and potential differences of the retinal blood flow velocity (BFV) remain largely unstudied but may be important in guiding eye selection as well as the design and interpretation of studies assessing or utilizing retinal BFV. The primary aim of this study was to determine inter-eye correlations in BFVs in healthy controls (HCs). Since prior studies raise the possibility of reduced BFV in MS eyes, a secondary aim was to compare retinal BFVs between MS eyes, grouped based on optic neuritis (ON) history and HC eyes.
methodsMacular arteriole and venule BFVs were determined using a retinal function imager (RFI) in both eyes of 20 HCs. One eye from a total of 38 MS patients comprising 13 eyes with ON (MSON) and 25 eyes without ON (MSNON) history were similarly imaged with RFI.
resultsOD (right) and OS (left) BFVs were not significantly different in arterioles (OD: 3.95 ± 0.59 mm/s; OS: 4.08 ± 0.60 mm/s,
conclusionsInter-eye arteriolar and venular BFVs do not differ significantly in HCs and are strongly correlated. Our findings support prior observations that arteriolar and venular BFVs may be reduced in MS eyes. Moreover, this seems to be the case in both MS eyes with and without a history of ON, raising the possibility of global blood flow alterations in MS. Future larger studies are needed to assess differences in BFVs between MSON and MSNON eyes.
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