ReviewFrontiers in pediatrics2018
Fluid Bolus Therapy in Pediatric Sepsis: Current Knowledge and Future Direction.
Review in Frontiers in pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Etiology, Pathophysiology and Mortality of Shock in Children in Low (Middle) Income Countries: A Systematic Review.Journal of tropical pediatrics · 2022Pooled it
- Speed of intravenous fluid on glycocalyx integrity and central blood volume in a porcine septic shock model.Intensive care medicine experimental · 2026Article
- Early inotropic support without fluid bolusWorld journal of clinical pediatrics · 2026Article
- Prognostic value of admission ionized calcium for short-term mortality in critically Ill children with sepsis: a single-center retrospective cohort study.Frontiers in pediatrics · 2026Article
- Perioperative fluid therapy in adults and children: a narrative review.Frontiers in medicine · 2025Review
- Fluid bolus therapy in pediatric sepsis: a narrative review.European journal of medical research · 2022Review
- Non-invasive Cardiac Output Monitoring and Assessment of Fluid Responsiveness in Children With Shock in the Emergency Department.Frontiers in pediatrics · 2022Article
- Near-fatal Panton-Valentine leukocidin-positiveWorld journal of critical care medicine · 2021Article
- Priorities for paediatric critical care research: a modified Delphi study by the Australian and New Zealand Intensive Care Society Paediatric Study Group.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2021Article
- Paediatric point-of-care ultrasound in a resource-limited Melanesian setting: A case series.Australasian journal of ultrasound in medicine · 2020Article
- Interventions for Pediatric Sepsis and Their Impact on Outcomes: A Brief Review.Healthcare (Basel, Switzerland) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a leading cause of morbidity and mortality in children with a worldwide prevalence in pediatric intensive care units of approximately 8%. Fluid bolus therapy (FBT) is a first line therapy for resuscitation of septic shock and has been a recommendation of international guidelines for nearly two decades. The evidence base supporting these guidelines are based on limited data including animal studies and case control studies. In recent times, evidence suggesting harm from fluid in terms of morbidity and mortality have generated interest in evaluating FBT. In view of this, studies of fluid restrictive strategies in adults and children have emerged. The complexity of studying FBT relates to several points. Firstly, the physiological and haemodynamic response to FBT including magnitude and duration is not well described in children. Secondly, assessment of the circulation is based on non-specific clinical signs and limited haemodynamic monitoring with limited physiological targets. Thirdly, FBT exists in a complex myriad of pathophysiological responses to sepsis and other confounding therapies. Despite this, a greater understanding of the role of FBT in terms of the physiological response and possible harm is warranted. This review outlines current knowledge and future direction for FBT in sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.