Evidence map›Paper›PMID 30410780›Full record

ReviewGlobal health, epidemiology and genomics2018

Association between early life antibiotic use and childhood overweight and obesity: a narrative review.

Uttara Partap, Sophie H Allcock, Edyth Parker, Deepti Gurdasani, Elizabeth H Young, Manjinder S Sandhu

Abstract readReview
In one paragraph

Review in Global health, epidemiology and genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Intrapartum Antibiotic Exposure and Body Mass Index in Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Uttara PartapDepartment of Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2531-1804
Sophie H AllcockDepartment of Medicine, University of Cambridge, Cambridge, UK.
Edyth ParkerDepartment of Veterinary Medicine, University of Cambridge, UK.
Deepti GurdasaniDepartment of Medicine, University of Cambridge, Cambridge, UK.
Elizabeth H YoungDepartment of Medicine, University of Cambridge, Cambridge, UK.
Manjinder S SandhuDepartment of Medicine, University of Cambridge, Cambridge, UK.

Funding

Medical Research Council MR/K013491/1
6 · The paper itself

Abstract

backgroundRecent research implicates antibiotic use as a potential contributor to child obesity risk. In this narrative review, we examine current observational evidence on the relation between antibiotic use in early childhood and subsequent measures of child body mass.

methodsWe searched PubMed, Web of Science and the Cochrane Library to identify studies that assessed antibiotic exposure before 3 years of age and subsequent measures of body mass or risk of overweight or obesity in childhood.

resultsWe identified 13 studies published before October 2017, based on a total of 6 81 332 individuals, which examined the relation between early life antibiotic exposure and measures of child body mass. Most studies did not appropriately account for confounding by indication for antibiotic use. Overall, we found no consistent and conclusive evidence of associations between early life antibiotic use and later child body mass [minimum overall adjusted odds ratio (aOR) reported: 1.01, 95% confidence interval (95% CI) 0.98-1.04,

conclusionsEvidence to date is insufficient to indicate that antibiotic use is an important risk factor for child obesity, or leads to clinically important differences in weight. Further comparable studies using routine clinical data may help clarify this association.

Indexed as

Antibioticschild obesitychild overweightearly life

Identifiers

PMID30410780
PMCPMC6218928

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.