ReviewF1000Research2018
What is the hologenome concept of evolution?
Review in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Applying evolutionary theory to understand host-microbiome evolution.Nature ecology & evolution · 2025Review
- Unravelling Changes in the Pinus radiata Root and Soil Microbiomes as a Function of Aridity.Global change biology · 2025Article
- Review
- Article
- Review
- Human holobionts: Metaorganisms hidden in plain sight?The Indian journal of medical research · 2024Article
- Modulation of Porcine Gut Microbiota and Microbiome: Hologenomic, Dietary, and Endogenous Factors.Pathogens (Basel, Switzerland) · 2024Article
- Evaluating the hologenome concept by analyzing the root-endosphere microbiota of chimeric plants.iScience · 2023Article
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- Investigating genetic diversity within the most abundant and prevalent non-pathogenic leaf-associated bacteria interacting withFrontiers in microbiology · 2022Article
- Analysis of the Gut Bacterial Community of Wild Larvae ofFrontiers in microbiology · 2022Article
- Article
- Animal development in the microbial world: Re-thinking the conceptual framework.Current topics in developmental biology · 2021Article
- Symbiosis and the Anthropocene.Symbiosis (Philadelphia, Pa.) · 2021Article
- The implication of metabolically active Vibrio spp. in the digestive tract of Litopenaeus vannamei for its post-larval development.Scientific reports · 2020Article
- Co-evolution in the Jungle: From Leafcutter Ant Colonies to Chromosomal Ends.Journal of molecular evolution · 2020Review
- Interspecies Communication in Holobionts by Non-Coding RNA Exchange.International journal of molecular sciences · 2020Review
- The manifold roles of microbial ribosomal peptide-based natural products in physiology and ecology.The Journal of biological chemistry · 2020Review
- Gut Bacteriome Analysis ofFrontiers in microbiology · 2020Article
- A Robust Symbiotic Relationship Between the CiliateFrontiers in microbiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All multicellular organisms are colonized by microbes, but a gestalt study of the composition of microbiome communities and their influence on the ecology and evolution of their macroscopic hosts has only recently become possible. One approach to thinking about the topic is to view the host-microbiome ecosystem as a "holobiont". Because natural selection acts on an organism's realized phenotype, and the phenotype of a holobiont is the result of the integrated activities of both the host and all of its microbiome inhabitants, it is reasonable to think that evolution can act at the level of the holobiont and cause changes in the "hologenome", or the collective genomic content of all the individual bionts within the holobiont. This relatively simple assertion has nevertheless been controversial within the microbiome community. Here, I provide a review of recent work on the hologenome concept of evolution. I attempt to provide a clear definition of the concept and its implications and to clarify common points of disagreement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.