Evidence map›Paper›PMID 30410718›Full record

ArticleParkinson's disease2018

Pisa Syndrome in Parkinson's Disease: Evidence for Bilateral Vestibulospinal Dysfunction.

Giulia Di Lazzaro, Tommaso Schirinzi, Maria Pia Giambrone, Roberta Di Mauro, Maria Giuseppina Palmieri, Camilla Rocchi, Michele Tinazzi, Nicola Biagio Mercuri, Stefano Di Girolamo, Antonio Pisani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinson's disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Giulia Di LazzaroDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Tommaso SchirinziDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Maria Pia GiambroneDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Roberta Di MauroDepartment of Otorhinolaryngology, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0002-2514-9894
Maria Giuseppina PalmieriDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Camilla RocchiDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Michele TinazziDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Nicola Biagio MercuriDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Stefano Di GirolamoDepartment of Otorhinolaryngology, University of Rome Tor Vergata, Rome, Italy.
Antonio PisaniDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0002-8432-594X
University of Rome Tor Vergata · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPisa syndrome (PS) is a postural complication of Parkinson's disease (PD). Yet, its pathophysiology remains unclear, although a multifactorial component is probable. Cervical vestibular evoked myogenic potentials (cVEMPs) explore vestibulospinal pathway, but they have not been measured yet in PD patients with PS (PDPS) to assess a potential vestibular impairment. MATERIALS AND

methodsWe enrolled 15 PD patients, 15 PDPS patients, and 30 healthy controls (HCs). They underwent neurological examination and were examined with Unified Parkinson's Disease Rating Scale II-III (UPDRSII-III), audiovestibular workup, and cVEMP recordings. Data were analysed with Chi-square, one-way ANOVA, multinomial regression, nonparametric, and Spearman's tests.

resultscVEMPs were significantly impaired in both PD and PDPS compared with HCs. PDPS exhibited more severe cVEMP abnormalities with prevalent bilateral loss of potentials, compared with the PD group, in which a prevalent unilateral loss was instead observed. No clinical-neurophysiological correlations emerged.

conclusionsDifferently from HC, cVEMPs are altered in PD. Severity of cVEMPs alterations increases from PD without PS to PDPS, suggesting an involvement of vestibulospinal pathway in the pathophysiology of PS. Our results provide evidence for a significant impairment of cVEMPs in PDPS patients and encourage further studies to test validity of cVEMPs as diagnostic and prognostic biomarkers of PD progression.

Identifiers

PMID30410718
PMCPMC6205319
OpenAlexW2896401843

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.