Evidence map›Paper›PMID 30410549›Full record

ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2018

Hyper IgE recurrent infection syndrome in South Asia: is there a different outcome?

Rajiva de Silva, Dhanushka Dasanayake, Manouri Senanayake, Ramya Ediriweera, Savithri Dias, Chandima Karunatilleke, Karen Brocas, Fariba Tahami, Suranjith Seneviratne

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rajiva de Silva1Medical Research Institute, Colombo, Sri Lanka.
Dhanushka Dasanayake1Medical Research Institute, Colombo, Sri Lanka.
Manouri Senanayake2Lady Ridgeway Hospital, Colombo, Sri Lanka.
Ramya Ediriweera2Lady Ridgeway Hospital, Colombo, Sri Lanka.
Savithri Dias3General Hospital, Kalutara, Sri Lanka.
Chandima Karunatilleke1Medical Research Institute, Colombo, Sri Lanka.
Karen Brocas4Institute of Infection and Immunity, Royal Free Hospital, London, UK.
Fariba Tahami4Institute of Infection and Immunity, Royal Free Hospital, London, UK.
Suranjith Seneviratne4Institute of Infection and Immunity, Royal Free Hospital, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyper IgE recurrent infection syndrome (HIES) is a rare immune deficiency, characterized by recurrent staphylococcal skin and lung abscesses, pneumonia and increased IgE levels. The majority of autosomal dominant HIES (AD HIGE) is due to hypomorphic mutations in the signal transducer and the activator of transcription 3 (STAT3) gene. CASE PRESENTATION: Five patients were diagnosed with HIES, based on the clinical criteria and scoring system developed at the National Institutes of Health (NIH), USA. The STAT3 gene was sequenced and previously described mutations were identified in all five patients. We compare the clinical features of our patients with those from Asia, Europe and the US.

conclusionEven though the number of patients is limited, there are some clinical differences in patients from South Asia compared to European and even East Asian patients. However, the mutations detected are located at hot spots seen in western and Asian patients with AD HIGE.

Indexed as

Autosomal dominant hyper IgEHyper IgE syndromeJob’s syndromePrimary immunodeficiencySTAT3 mutation

Identifiers

PMID30410549
PMCPMC6214173

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