ArticleInterventional neurology2018
Ghost Infarct Core and Admission Computed Tomography Perfusion: Redefining the Role of Neuroimaging in Acute Ischemic Stroke.
Article in Interventional neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Selection by Noncontrast Computed Tomography With or Without Computed Tomography Angiography Versus Computed Tomography Perfusion for Endovascular Therapy in Patients With Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2025Pooled it
- Thrombectomy with and without computed tomography perfusion imaging for large-vessel occlusion stroke in the extended time window: a meta-analysis of randomized clinical trials.Frontiers in neurology · 2023Pooled it
- Assessing the diagnostic accuracy of CT perfusion: a systematic review.Frontiers in neurology · 2023Pooled it
- Challenges and Adjunctive Use of CT Perfusion (CTP) in Acute Stroke: Pitfalls, False Negatives, and Diagnostic Clues for Stroke Mimics.Current neurology and neuroscience reports · 2026Review
- Predictors of Unfavorable Outcome After Endovascular Thrombectomy for Acute Basilar Artery Occlusion with Mild Symptoms.Clinical neuroradiology · 2026Article
- Revisiting infarct core assessment: venous outflow and net water uptake as modifiers of outcome after stroke thrombectomy.European radiology · 2026Article
- How Do Patient Outcomes in Mechanical Thrombectomy for Large-Core Stroke Vary Based on Neuroimaging Modalities Used for Patient Selection? A Multicenter Multinational Study.Translational stroke research · 2025Article
- The Role of CT Perfusion in the Evaluation and Management of Acute Ischemic Stroke-A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Prolonged Venous Transit on Perfusion Imaging Is Associated with Longer Lengths of Stay in Acute Large Vessel Occlusions.AJNR. American journal of neuroradiology · 2025Article
- Ct-Perfusion Absolute Ghost Infarct Core Is a Rare Phenomenon Associated with Poor Collateral Status in Acute Ischemic Stroke Patients.Journal of clinical medicine · 2025Article
- The CT collateral map: collateral perfusion estimation and baseline lesion assessment after acute anterior circulation ischemic stroke.La Radiologia medica · 2025Observational
- Utility of automated CT perfusion software in acute ischemic stroke with large and medium vessel occlusion.Annals of clinical and translational neurology · 2024Article
- Endovascular Thrombectomy for Acute Ischemic Stroke : Current Concept in Management.Journal of Korean Neurosurgical Society · 2024Article
- Understanding Bias in Artificial Intelligence: A Practice Perspective.AJNR. American journal of neuroradiology · 2024Article
- Reducing False-Positives in CT Perfusion Infarct Core Segmentation Using Contralateral Local Normalization.AJNR. American journal of neuroradiology · 2024Article
- Prevalence of "Ghost Infarct Core" after Endovascular Thrombectomy.AJNR. American journal of neuroradiology · 2024Article
- Article
- Near-Complete Reversal of Large Diffusion-Weighted Imaging Lesion after Thrombectomy: A Case Report and Literature Review.Cerebrovascular diseases extra · 2024Review
- Application of imaging modalities for endovascular thrombectomy of large core infarcts in clinical practice.Frontiers in neurology · 2024Review
- Automated advanced imaging in acute ischemic stroke. Certainties and uncertainties.European journal of radiology open · 2023Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDetermining the size of infarct extent is crucial to elect patients for reperfusion therapies. Computed tomography perfusion (CTP) based on cerebral blood volume may overestimate infarct core on admission and consequently include ghost infarct core (GIC) in a definitive lesional area. PURPOSE: Our goal was to confirm and better characterize the GIC phenomenon using CTP cerebral blood flow (CBF) as the reference parameter to determine infarct core.
methodsWe performed a retrospective, single-center analysis of consecutive thrombectomies of middle cerebral or intracranial internal carotid artery occlusions considering noncontrast CT Alberta Stroke Program Early CT Score ≥6 in patients with pretreatment CTP. We used the RAPID® software to measure admission infarct core based on initial CBF. The final infarct was extracted from follow-up CT. GIC was defined as initial core minus final infarct > 10 mL.
resultsA total of 123 patients were included. The median National Institutes of Health Stroke Scale score was 18 (13-20), the median time from symptoms to CTP was 188 (67-288) min, and the recanalization rate (Thrombolysis in Cerebral Infarction score 2b, 2c, or 3) was 83%. Twenty patients (16%) presented with GIC. GIC was associated with shorter time to recanalization (150 [105-291] vs. 255 [163-367] min,
conclusionsCTP CBF < 30% may overestimate infarct core volume, especially in patients imaged in the very early time window and with fast complete reperfusion. Therefore, the CTP CBF technique may exclude patients who would benefit from endovascular treatment.
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