Evidence map›Paper›PMID 30410447›Full record

ArticleFrontiers in physiology2018

A Ciliary Protein EVC2/LIMBIN Plays a Critical Role in the Skull Base for Mid-Facial Development.

Anshul K Kulkarni, Ke'ale W Louie, Marilia Yatabe, Antonio Carlos de Oliveira Ruellas, Yoshiyuki Mochida, Lucia H S Cevidanes, Yuji Mishina, Honghao Zhang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Neural crest-specific disruption of Evc2 provides an animal model to study the temporomandibular joint development and homeostasis in response to jaw loading.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  2. Cranial Neural Crest Specific Deletion ofInternational journal of molecular sciences · 2023
    Article
  3. Article
  4. Article
  5. Review
  6. Cranial Base Synchondrosis: Chondrocytes at the Hub.International journal of molecular sciences · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anshul K KulkarniDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
Ke'ale W LouieDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
Marilia YatabeDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
Antonio Carlos de Oliveira RuellasDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
Yoshiyuki MochidaDepartment of Molecular and Cell Biology, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA, United States.
Lucia H S CevidanesDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
Yuji MishinaDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
Honghao ZhangDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · USBoston University · US

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
Quantification of 3D Bony Changes in Temporomandibular Joint OsteoarthritisR01DE024450 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Lucia H Cevidanes · 2013 to 2026
$5.5M
Molecular pathogenesis of craniosynostosis caused by enhanced BMP signalingR01DE020843 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI · 2010 to 2019
$4.9M
EVC2: A novel modulator in tooth developmentR01DE019527 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOCHIDA, YOSHIYUKI · 2009 to 2013
$2.0M
MicroCT 100S10RR026475 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2010 to 2010
$381k
The function of Hedgehog signaling in maintaining the dental mesenchymal stem cellsR03DE027456 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, HONGHAO · 2018 to 2019
$312k
NCRR NIH HHS S10 RR026475NIAMS NIH HHS P30 AR069620NIDCR NIH HHS R01 DE019527NIDCR NIH HHS R01 DE020843NIDCR NIH HHS R01 DE024450NIDCR NIH HHS R03 DE027456NIDCR NIH HHS T32 DE007057
6 · The paper itself

Abstract

Ellis-van Creveld (EvC) syndrome is an autosomal recessive chondrodysplastic disorder. Affected patients present a wide spectrum of symptoms including short stature, postaxial polydactyly, and dental abnormalities. We previously disrupted

Indexed as

ciliopathyEvc2EvC syndromeLimbinmid-facial defectsneural crestskull base

Identifiers

PMID30410447
PMCPMC6210651
OpenAlexW2898383130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.