ArticleFrontiers in neural circuits2018
Methods for Mapping Neuronal Activity to Synaptic Connectivity: Lessons From Larval Zebrafish.
Article in Frontiers in neural circuits, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Building neuroanatomical resources for three-spined sticklebacks: Brain areas important for social behavior.bioRxiv : the preprint server for biology · 2026Article
- Zebrafish as a translational model for peptide-mediated synaptic dysfunction related to obesity.Frontiers in synaptic neuroscience · 2026Review
- Quantitative evaluation of embedding resins for volume electron microscopy.Frontiers in neuroscience · 2024Article
- Studying zebrafish nervous system structure and function in health and disease with electron microscopy.Development, growth & differentiation · 2023Review
- Volumetric light sheet imaging with adaptive optics correction.Biomedical optics express · 2023Article
- Reconstructing neural circuits using multiresolution correlated light and electron microscopy.Frontiers in neural circuits · 2022Article
- Larval Zebrafish as a Model for Mechanistic Discovery in Mental Health.Frontiers in molecular neuroscience · 2022Review
- Whole-brain interactions underlying zebrafish behavior.Current opinion in neurobiology · 2020Review
- Whitening of odor representations by the wiring diagram of the olfactory bulb.Nature neuroscience · 2020Article
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2 authors.
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Abstract
For a mechanistic understanding of neuronal circuits in the brain, a detailed description of information flow is necessary. Thereby it is crucial to link neuron function to the underlying circuit structure. Multiphoton calcium imaging is the standard technique to record the activity of hundreds of neurons simultaneously. Similarly, recent advances in high-throughput electron microscopy techniques allow for the reconstruction of synaptic resolution wiring diagrams. These two methods can be combined to study both function and structure in the same specimen. Due to its small size and optical transparency, the larval zebrafish brain is one of the very few vertebrate systems where both, activity and connectivity of all neurons from entire, anatomically defined brain regions, can be analyzed. Here, we describe different methods and the tools required for combining multiphoton microscopy with dense circuit reconstruction from electron microscopy stacks of entire brain regions in the larval zebrafish.
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