Evidence map›Paper›PMID 30410385›Full record

ArticlePharmacogenomics and personalized medicine2018

Creating and validating a warfarin pharmacogenetic dosing algorithm for Colombian patients.

Jubby Marcela Galvez, Carlos Martin Restrepo, Nora Constanza Contreras, Clara Alvarado, Carlos-Alberto Calderón-Ospina, Nidia Peña, Ricardo A Cifuentes, Daniela Duarte, Paul Laissue, Dora Janeth Fonseca

Open access · goldAbstract read
In one paragraph

Article in Pharmacogenomics and personalized medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Ethnic Diversity and Warfarin Pharmacogenomics.Frontiers in pharmacology · 2022
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Functionally Significant Coumarin-Related Variant Alleles and Time to Therapeutic Range in Chilean Cardiovascular Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jubby Marcela GalvezGENIUROS Research Group, Center For Research in Genetics and Genomics - CIGGUR, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia, dora.fonseca@urosario.edu.co.
Carlos Martin RestrepoGENIUROS Research Group, Center For Research in Genetics and Genomics - CIGGUR, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia, dora.fonseca@urosario.edu.co.
Nora Constanza ContrerasGENIUROS Research Group, Center For Research in Genetics and Genomics - CIGGUR, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia, dora.fonseca@urosario.edu.co.
Clara AlvaradoGENIUROS Research Group, Center For Research in Genetics and Genomics - CIGGUR, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia, dora.fonseca@urosario.edu.co.
Carlos-Alberto Calderón-OspinaGENIUROS Research Group, Center For Research in Genetics and Genomics - CIGGUR, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia, dora.fonseca@urosario.edu.co.
Nidia PeñaGENIUROS Research Group, Center For Research in Genetics and Genomics - CIGGUR, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia, dora.fonseca@urosario.edu.co.
Ricardo A CifuentesArea of Basic Sciences, College of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia.
Daniela DuarteGENIUROS Research Group, Center For Research in Genetics and Genomics - CIGGUR, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia, dora.fonseca@urosario.edu.co.
Paul LaissueGENIUROS Research Group, Center For Research in Genetics and Genomics - CIGGUR, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia, dora.fonseca@urosario.edu.co.
Dora Janeth FonsecaGENIUROS Research Group, Center For Research in Genetics and Genomics - CIGGUR, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia, dora.fonseca@urosario.edu.co.
Universidad del Rosario · COMilitary University Nueva Granada · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWarfarin is an oral anticoagulant associated with adverse reaction to drugs due to wide inter- and intra-individual dosage variability. Warfarin dosage has been related to non-genetic and genetic factors. PATIENTS AND

methodsWe genotyped

resultsMedian weekly prescribed warfarin dosage was significantly lower in patients having the

conclusionOur results describe and validate the first algorithm for predicting warfarin maintenance in a Colombian mestizo population and have contributed toward the understanding of pharmacogenetics in a Latin American population subgroup.

Indexed as

adverse drug reactionanticoagulantsgene frequencygenetic polymorphism

Identifiers

PMID30410385
PMCPMC6198877
OpenAlexW2896370986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.