Evidence map›Paper›PMID 30410336›Full record

ArticleInternational journal of nanomedicine2018

Inducing angiogenesis with the controlled release of nitric oxide from biodegradable and biocompatible copolymeric nanoparticles.

Chungmo Yang, Hae Hyun Hwang, Soohyun Jeong, Deokwon Seo, Yoon Jeong, Dong Yun Lee, Kangwon Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  15. Antioxidants (Basel, Switzerland) · 2021
    Article
  16. Nano-Medicine in the Cardiovascular System.Frontiers in pharmacology · 2021
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chungmo YangDepartment of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea, kangwonlee@snu.ac.kr.
Hae Hyun HwangDepartment of Bioengineering, College of Engineering, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University, Seoul 04763, Republic of Korea, dongyunlee@hanyang.ac.kr.
Soohyun JeongDepartment of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea, kangwonlee@snu.ac.kr.
Deokwon SeoDepartment of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea, kangwonlee@snu.ac.kr.
Yoon JeongDepartment of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea, kangwonlee@snu.ac.kr.
Dong Yun LeeDepartment of Bioengineering, College of Engineering, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University, Seoul 04763, Republic of Korea, dongyunlee@hanyang.ac.kr.
Kangwon LeeDepartment of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea, kangwonlee@snu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNitric oxide (NO) can be clinically applied at low concentrations to regulate angiogenesis. However, studies using small molecule NO donors ( MATERIALS AND

methodsThe mPEG-PLGA copolymers were synthesized by typical ring-opening polymerization of lactide, glycolide and mPEG as macroinitiators. Double emulsion methods were used to prepare mPEG-PLGA NPs incorporating hydrophilic NONOate (dieth-ylenetriamine NONOate).

resultsThis liposomal NP encapsulates hydrophilic diethylenetriamine NONOate (70%±4%) more effectively than other previously reported materials. The application of NO-NPs at different ratios resulted in varying NO-release profiles with no significant cytotoxicity in various cell types: normal cells (fibroblasts, human umbilical vein endothelial cells and epithelial cells) and cancer cells (C6, A549 and MCF-7). The angiogenic potential of NO-NPs was confirmed in vitro by tube formation and ex vivo through an aorta ring assay. Tubular formation increased 189.8% in NO-NP-treated groups compared with that in the control group. Rat aorta exhibited robust sprouting angiogenesis in response to NO-NPs, indicating that NO was produced by polymeric NPs in a sustained manner.

conclusionThese findings provide initial results for an angiogenesis-related drug development platform by a straightforward method with biocompatible polymers.

Indexed as

A549 CellsAngiogenesis Inducing AgentsAnimalsBiocompatible MaterialsCell DeathDelayed-Action PreparationsDrug CarriersEmulsionsHumansHuman Umbilical Vein Endothelial CellsMaleMiceNanoparticlesNitric OxideParticle SizePolyestersAngiogenesis Inducing AgentsBiocompatible MaterialsDelayed-Action PreparationsDrug CarriersEmulsionsmethoxypolyethyleneglycol-poly(lactic-co-glycolic acid)Nitric OxidePolyestersPolyethylene Glycolsamphiphilic polymersliposomal nanoparticleslow concentration of nitric oxidemPEG-PLGA nanoparticlessprouting angiogenesis

Identifiers

PMID30410336
PMCPMC6199220

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.