Evidence map›Paper›PMID 30410122›Full record

ArticleScientific reports2018

A practical protocol for measurements of spinal cord functional connectivity.

Robert L Barry, Benjamin N Conrad, Seth A Smith, John C Gore

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
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  8. Characteristic BOLD signals are detectable in white matter of the spinal cord at rest and after a stimulus.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Robert L BarryAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA. Robert.Barry@mgh.Harvard.edu.
Benjamin N ConradVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Seth A SmithVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John C GoreVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NEUL, JEFFREY L · 2015 to 2019
$7.1M
Structural and Functional MRI of the Cervical Spinal Cord in Multiple SclerosisR01NS109114 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SMITH, SETH A · 2018 to 2022
$1.7M
Resting State FMRI as a Biomarker of Functional Integrity of Spinal CordR01NS104149 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORE, JOHN C · 2017 to 2020
$1.5M
Institutional Predoctoral Training Program in Biomedical Imaging ScienceT32EB014841 · NIBIB · VANDERBILT UNIVERSITY · PI GORE, JOHN C · 2013 to 2017
$771k
Functional Imaging and resting state connectivity in human spinal cord at 7 TeslaR00EB016689 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BARRY, ROBERT L · 2016 to 2018
$747k
In Vivo Macromolecular and Protein-Based MRI in the Spinal Cord of MS PatientsR21NS087465 · NINDS · VANDERBILT UNIVERSITY · PI SMITH, SETH A · 2014 to 2015
$431k
Investigation of Resting State Functional Connectivity in the Human Spinal CordR21NS081437 · NINDS · VANDERBILT UNIVERSITY · PI GORE, JOHN C · 2013 to 2014
$427k
Functional Imaging and Resting State Connectivity in Human Spinal Cord at 7 TeslaK99EB016689 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BARRY, ROBERT L · 2014 to 2015
$178k
NCATS NIH HHS UL1 TR000445NCRR NIH HHS UL1 RR024975NIBIB NIH HHS K99 EB016689NIBIB NIH HHS R00 EB016689NIBIB NIH HHS T32 EB014841NICHD NIH HHS U54 HD083211NINDS NIH HHS R01 NS104149NINDS NIH HHS R01 NS109114NINDS NIH HHS R21 NS081437NINDS NIH HHS R21 NS087465
6 · The paper itself

Abstract

Resting state functional magnetic resonance imaging (fMRI) has been used to study human brain function for over two decades, but only recently has this technique been successfully translated to the human spinal cord. The spinal cord is structurally and functionally unique, so resting state fMRI methods developed and optimized for the brain may not be appropriate when applied to the cord. This report therefore investigates the relative impact of different acquisition and processing choices (including run length, echo time, and bandpass filter width) on the detectability of resting state spinal cord networks at 3T. Our results suggest that frequencies beyond 0.08 Hz should be included in resting state analyses, a run length of ~8-12 mins is appropriate for reliable detection of the ventral (motor) network, and longer echo times - yet still shorter than values typically used for fMRI in the brain - may increase the detectability of the dorsal (sensory) network. Further studies are required to more fully understand and interpret the nature of resting state spinal cord networks in health and in disease, and the protocols described in this report are designed to assist such studies.

Indexed as

AdultFemaleHealthy VolunteersHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleModels, NeurologicalRestSpinal CordYoung Adult

Identifiers

PMID30410122
PMCPMC6224587

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.