Evidence map›Paper›PMID 30410049›Full record

ArticleScientific reports2018

Homotaurine, a safe blood-brain barrier permeable GABA

Jide Tian, Hoa Dang, Martin Wallner, Richard Olsen, Daniel L Kaufman

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 47 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. CD8+ Regulatory T Cells.Annual review of immunology · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Physiology of γ-aminobutyric acid production byApplied and environmental microbiology · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. GABAFrontiers in pharmacology · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jide TianDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA. jtian@mednet.ucla.edu.
Hoa DangDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA.
Martin WallnerDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA.
Richard OlsenDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA.
Daniel L KaufmanDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA. dkaufman@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Unique pharmacology of ligand sites on delta subunit-containing GABA-A receptorsR01AA021213 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLSEN, RICHARD W, WALLNER, MARTIN · 2013 to 2019
$1.6M
Reversal of T1D in NOD mice using a safe combination therapyR01DK092480 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAUFMAN, DANIEL · 2012 to 2015
$1.3M
NIAAA NIH HHS R01 AA021213NIDDK NIH HHS R01 DK092480
6 · The paper itself

Abstract

There is a need for treatments that can safely promote regulatory lymphocyte responses. T cells express GABA receptors (GABA

Indexed as

Administration, OralAnimalsBlood-Brain BarrierDisease Models, AnimalGABA AgonistsMiceMice, Inbred C57BLMultiple SclerosisTaurineTh17 CellsTh1 CellsT-Lymphocytes, RegulatoryGABA AgonistsTaurinetramiprosate

Identifiers

PMID30410049
PMCPMC6224391
OpenAlexW2899464647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.