Evidence map›Paper›PMID 30410008›Full record

ArticleThe Journal of antibiotics2019

Antimicrobial agent isolated from Coptidis rhizome extract incubated with Rhodococcus sp. strain BD7100.

Kazuki Ishikawa, Kazunori Takahashi, Syun Hosoi, Hisashi Takeda, Hinaka Yoshida, Daigo Wakana, Masayoshi Tsubuki, Fumihiko Sato, Motoaki Tojo, Tomoo Hosoe

Abstract read
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In one paragraph

Article in The Journal of antibiotics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kazuki IshikawaDepartment of Organic Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.
Kazunori TakahashiInstitute of Medical Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan. takakazu@hoshi.ac.jp.ORCID http://orcid.org/0000-0001-5418-0586
Syun HosoiDepartment of Organic Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.
Hisashi TakedaDepartment of Organic Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.
Hinaka YoshidaDepartment of Organic Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.
Daigo WakanaDepartment of Organic Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.
Masayoshi TsubukiInstitute of Medical Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.
Fumihiko SatoDepartment of Plant Gene and Totipotency, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto, 606-8502, Japan.
Motoaki TojoGraduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1, Gakuen-cho, Nakaku, Sakai, Osaka, 599-8531, Japan.
Tomoo HosoeDepartment of Organic Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan. hosoe@hoshi.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coptidis rhizome (CR) is a widely used herbal medicine that contains protoberberine-type alkaloids. CR extract exhibits various pharmacologic activities. A previous study reported the isolation of Rhodococcus sp. strain BD7100 as a berberine (BBR)-utilizing bacterium, and the BBR-degradation pathway has been investigated. When we incubated strain BD7100 cells with CR extract, the number of viable cells declined with the degradation of components in the CR extract, and the culture broth exhibited antibacterial activity against strain BD7100. These results suggest that CR extract cultured in the presence of strain BD7100 contains one or more antibacterial agents. In this study, we isolated coptirhoquinone A (1) from CR extract incubated with strain BD7100 in Luria-Bertani (LB) medium, and the structure was elucidated using NMR and MS analysis. We also report the total synthesis and antimicrobial activities of 1 against bacteria, fungi, and Pythium sp.

Indexed as

Anti-Bacterial AgentsAntifungal AgentsAntiprotozoal AgentsBerberineCoptis chinensisDrugs, Chinese HerbalFungiPlant ExtractsPythiumQuinonesRhodococcusAnti-Bacterial AgentsAntifungal AgentsAntiprotozoal AgentsBerberineCoptidis rhizoma extractDrugs, Chinese HerbalPlant ExtractsQuinones

Identifiers

PMID30410008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.