ArticleNature communications2018
Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Apoptosis promotes fertility in Caenorhabditis elegans by maintaining functional germline morphology.Development (Cambridge, England) · 2026Article
- TaggingbioRxiv : the preprint server for biology · 2026Article
- Apoptosis promotes fertility inbioRxiv : the preprint server for biology · 2025Article
- Animal septins contain functional transmembrane domains.Current biology : CB · 2025Article
- Lessons on the force-form-function connection in cell biology from modeling a syncytial germline.Current opinion in cell biology · 2025Review
- Actomyosin-mediated apical constriction promotes physiological germ cell death in C. elegans.PLoS biology · 2024Article
- Article
- Mechanical control of neural plate folding by apical domain alteration.Nature communications · 2023Article
- Actin-capping protein regulates actomyosin contractility to maintain germline architecture in C. elegans.Development (Cambridge, England) · 2023Article
- Go with the flow - bulk transport by molecular motors.Journal of cell science · 2023Review
- Visualizing and quantifying molecular and cellular processes in Caenorhabditis elegans using light microscopy.Genetics · 2022Review
- Live-cell Imaging and Analysis of Germline Stem Cell Mitosis inBio-protocol · 2022Article
- Uncoupling cell division and cytokinesis during germline development in metazoans.Frontiers in cell and developmental biology · 2022Review
- Communal living: the role of polyploidy and syncytia in tissue biology.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2021Review
- The initial expansion of the C. elegans syncytial germ line is coupled to incomplete primordial germ cell cytokinesis.Development (Cambridge, England) · 2021Article
- A hydraulic instability drives the cell death decision in the nematode germline.Nature physics · 2021Article
- The primordial germ line is refractory to perturbations of actomyosin regulator function inmicroPublication biology · 2021Article
- Stem cell niche exit ineLife · 2020Article
- Novel cytokinetic ring components drive negative feedback in cortical contractility.Molecular biology of the cell · 2020Article
- Endogenous expression of UNC-59/Septin inmicroPublication biology · 2019Article
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Authors and funding
7 authors.
Funding
Abstract
Syncytial architecture is an evolutionarily-conserved feature of the germline of many species and plays a crucial role in their fertility. However, the mechanism supporting syncytial organization is largely unknown. Here, we identify a corset-like actomyosin structure within the syncytial germline of Caenorhabditis elegans, surrounding the common rachis. Using laser microsurgery, we demonstrate that actomyosin contractility within this structure generates tension both in the plane of the rachis surface and perpendicular to it, opposing membrane tension. Genetic and pharmacological perturbations, as well as mathematical modeling, reveal a balance of forces within the gonad and show how changing the tension within the actomyosin corset impinges on syncytial germline structure, leading, in extreme cases, to sterility. Thus, our work highlights a unique tissue-level cytoskeletal structure, and explains the critical role of actomyosin contractility in the preservation of a functional germline.
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