ArticleScientific reports2018
Quantitative morphometric analysis of adult teleost fish by X-ray computed tomography.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Development of the zebrafish foveal analogue: a quantitative atlas of high-acuity zone growth and retinal regionalisation.Biology open · 2026Article
- Bioimaging of sense organs and the central nervous system in extant fishes and reptiles in situ: A review.Anatomical record (Hoboken, N.J. : 2007) · 2026Review
- Ocular Morphology and Clinical Ophthalmic Parameters of Nile Tilapia Oreochromis niloticus.Veterinary ophthalmology · 2026Article
- The sex of organ geometry.Nature · 2024Article
- Visualisation of gene expression within the context of tissues using an X-ray computed tomography-based multimodal approach.Scientific reports · 2024Article
- Enhanced contrast synchrotron X-ray microtomography for describing skeleton-associated soft tissue defects in zebrafish mutants.Frontiers in endocrinology · 2023Article
- Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish.Cardiovascular research · 2022Article
- A wide-field micro-computed tomography detector: micron resolution at half-centimetre scale.Journal of synchrotron radiation · 2022Article
- Normal stages of embryonic development of a brood parasite, the rosy bitterling Rhodeus ocellatus (Teleostei: Cypriniformes).Journal of morphology · 2021Article
- Turning the Curve Into Straight: Phenogenetics of the Spine Morphology and Coordinate Maintenance in the Zebrafish.Frontiers in cell and developmental biology · 2021Review
- Introducing Biomedisa as an open-source online platform for biomedical image segmentation.Nature communications · 2020Article
- Synchrotron microtomography applied to the volumetric analysis of internal structures of Thoropa miliaris tadpoles.Scientific reports · 2020Article
- Whole Animal Imaging of Drosophila melanogaster using Microcomputed Tomography.Journal of visualized experiments : JoVE · 2020Article
- Radiological characterization of gilthead seabream (Sparus aurata) fat by X-ray micro-computed tomography.Scientific reports · 2020Article
- Micro-computed tomography as a platform for exploringDevelopment (Cambridge, England) · 2019Article
- An interactive and intuitive visualisation method for X-ray computed tomography data of biological samples in 3D Portable Document Format.Scientific reports · 2019Article
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6 authors.
Funding
Abstract
Vertebrate models provide indispensable paradigms to study development and disease. Their analysis requires a quantitative morphometric study of the body, organs and tissues. This is often impeded by pigmentation and sample size. X-ray micro-computed tomography (micro-CT) allows high-resolution volumetric tissue analysis, largely independent of sample size and transparency to visual light. Importantly, micro-CT data are inherently quantitative. We report a complete pipeline of high-throughput 3D data acquisition and image analysis, including tissue preparation and contrast enhancement for micro-CT imaging down to cellular resolution, automated data processing and organ or tissue segmentation that is applicable to comparative 3D morphometrics of small vertebrates. Applied to medaka fish, we first create an annotated anatomical atlas of the entire body, including inner organs as a quantitative morphological description of an adult individual. This atlas serves as a reference model for comparative studies. Using isogenic medaka strains we show that comparative 3D morphometrics of individuals permits identification of quantitative strain-specific traits. Thus, our pipeline enables high resolution morphological analysis as a basis for genotype-phenotype association studies of complex genetic traits in vertebrates.
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