Evidence map›Paper›PMID 30409912›Full record

ArticleThe Journal of biological chemistry2019

Dynamic acetylation of the kinetochore-associated protein HEC1 ensures accurate microtubule-kinetochore attachment.

Gangyin Zhao, Yubao Cheng, Ping Gui, Meiying Cui, Wei Liu, Wenwen Wang, Xueying Wang, Mahboob Ali, Zhen Dou, Liwen Niu and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Hec1/Ndc80 Tail Domain Function at the Kinetochore-Microtubule Interface.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Gangyin ZhaoFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and.ORCID 0000-0003-2872-8143
Yubao ChengFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and.ORCID 0000-0001-6967-1433
Ping GuiFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and.
Meiying CuiFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and.
Wei LiuFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and.
Wenwen WangFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and.
Xueying WangFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and.
Mahboob AliFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and.
Zhen DouFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and.
Liwen NiuFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and.
Haiyan LiuFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and.
Leonard Andersonthe Keck Center for Cellular Dynamics and Organoids Plasticity, Morehouse School of Medicine, Atlanta, Georgia 30310.
Ke RuanFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and.
Jingjun HongFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and jjhong@ustc.edu.cn.
Xuebiao YaoFrom the Division of Molecular and Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, University of Science and Technology of the China School of Life Sciences, Chinese Academy of Sciences Center of Excellence on Molecular Cell Sciences, Hefei 230027, China and yaoxb@ustc.edu.cn.
Chinese Academy of Sciences · CNMorehouse School of Medicine · USUniversity of Science and Technology of China · CN

Funding

The function of ezrin in stimulus-coupled acid secretionR01DK056292 · NIDDK · UNIVERSITY OF WISCONSIN MADISON · PI YAO, XUEBIAO · 1999 to 2012
$2.5M
Function of ACAP4 in CCL18-stimulated breast cancer metastasisR01CA164133 · NCI · MOREHOUSE SCHOOL OF MEDICINE · PI YAO, XUEBIAO · 2012 to 2016
$1.4M
FUNCTION OF MST4-EZRIN-ACAP4 SIGNALING IN GASTRIC PARIETAL CELL SECRETION AND HOMEOSTASISR01DK115812 · NIDDK · MOREHOUSE SCHOOL OF MEDICINE · PI YAO, XUEBIAO · 2017 to 2019
$967k
NCI NIH HHS R01 CA164133NIDDK NIH HHS R01 DK056292NIDDK NIH HHS R01 DK115812
6 · The paper itself

Abstract

Faithful chromosome segregation during mitosis is critical for maintaining genome integrity in cell progeny and relies on accurate and robust kinetochore-microtubule attachments. The NDC80 complex, a tetramer comprising kinetochore protein HEC1 (HEC1), NDC80 kinetochore complex component NUF2 (NUF2), NDC80 kinetochore complex component SPC24 (SPC24), and SPC25, plays a critical role in kinetochore-microtubule attachment. Mounting evidence indicates that phosphorylation of HEC1 is important for regulating the binding of the NDC80 complex to microtubules. However, it remains unclear whether other post-translational modifications, such as acetylation, regulate NDC80-microtubule attachment during mitosis. Here, using pulldown assays with HeLa cell lysates and site-directed mutagenesis, we show that HEC1 is a

Indexed as

MitosisAcetylationChromosome SegregationCytoskeletal ProteinsHEK293 CellsHeLa CellsHumansKinetochoresLysine Acetyltransferase 5MicrotubulesModels, MolecularNuclear ProteinsProtein Interaction MapsSirtuin 1Cytoskeletal ProteinsKAT5 protein, humanLysine Acetyltransferase 5NDC80 protein, humanNuclear ProteinsSIRT1 protein, humanSirtuin 1chromosomal segregationHEC1kinetochoremicrotubulemitosismitotic spindleNDC80 complexNUF2protein acylationspindle assemblyTIP60

Identifiers

PMID30409912
PMCPMC6333894
OpenAlexW2899685047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.